Obesity is a growing epidemic in developed countries. Obese individuals are susceptible to
comorbidities, including cardiovascular disease and metabolic disorder. Increasing the
ability of adipose tissue to expend excess energy could improve protection from obesity.
One promising target is microRNA (miR)-155-5p. We demonstrate that deletion of miR-155 (-
5p and-3p) in female mice prevents diet-induced obesity. Body weight gain did not differ
between wild-type (WT) and miR-155 knockout (KO) mice fed control diet (CD); however …