Targeting microbial biofilms: current and prospective therapeutic strategies

H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
… their effectiveness, and microbial proteases may further diminish AMP potency 106 . In addition,
… Furthermore, structurally nanoengineered AMP polymers exhibited potent killing activity …

[HTML][HTML] Promising therapeutic strategies against microbial biofilm challenges

K Zhang, X Li, C Yu, Y Wang - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
biofilm drug resistance and recent progress in alternative therapies and promising strategies
against microbial biofilms. … coli) also exert potent antibacterial activity against closely related …

Dissecting the therapeutic potency of antimicrobial peptides against microbial biofilms

P Gupta, P Mishra, R Prasad… - Current Protein and …, 2021 - ingentaconnect.com
… for their anti-biofilm potency. It is worth noting that the majority of the anti-biofilm studies were
performed against bacterial biofilm, while few studies are on fungal biofilms. The following …

[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
… The highly antibiotic resistant property of biofilms urgently calls for potent antimicrobial
agents and novel antibiofilm strategies. Researchers have made a lot of efforts in this field. Here …

Strategies to improve the potency of oxazolidinones towards bacterial biofilms

ARN Ndukwe, S Wiedbrauk, NRB Boase… - Chemistry–An Asian …, 2022 - Wiley Online Library
… in the planktonic state and are ineffective against bacterial biofilms. The oxazolidinones, …
more potent antibiotic compounds with activity against bacterial biofilms, we review the biofilm

Biofilms: an extra hurdle for effective antimicrobial therapy

P Cos, K Tote, T Horemans… - Current pharmaceutical …, 2010 - ingentaconnect.com
… of biofilms, this review discusses the different resistance mechanisms that lead to increased
biofilm-… Adherent communities are involved in at least 65% of all human bacterial infections, …

Use of antimicrobial peptides against microbial biofilms: advantages and limits

G Batoni, G Maisetta… - Current medicinal …, 2011 - ingentaconnect.com
… The chain length of an AMP might be a critical factor for the potency of its anti-biofilm activity
and mechanism of action. In a recent structure-activity study, a series of linear peptides with …

[HTML][HTML] Targeting biofilms therapy: current research strategies and development hurdles

Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
… In this review, we focus on multiple therapeutic strategies that are currently being developed
… mechanisms of biofilms. We thoroughly discuss the current biofilm targeting strategies from …

Bacterial biofilms: a diagnostic and therapeutic challenge

CA Fux, P Stoodley, L Hall-Stoodley… - … anti-infective therapy, 2003 - Taylor & Francis
… aeruginosa, or any type of multiresistant bacteria, there are no potent oral antimicrobial
agents. These cases require the removal of any foreign body material for a definitive cure [7]. …

Antimicrobial strategies effective against infectious bacterial biofilms

M Simoes - Current medicinal chemistry, 2011 - ingentaconnect.com
… This review will focus on the recent research on therapeutic antimicrobials with biofilm … its
potent activity against the target bacteria [55]. This antibiotic was found to inhibit staphylococcal …