Microglial diversity in neuropathic pain

M Tsuda, T Masuda, K Kohno - Trends in Neurosciences, 2023 - cell.com
… evidence for the role of spinal microglia in the induction of neuropathic pain, as well as in its
… of microglia crucial for remission. The distinct roles of diverse microglia challenge previous …

Microglia and neuropathic pain

K Inoue, M Tsuda - Glia, 2009 - Wiley Online Library
… producing neuropathic pain, focusing on the roles of microglia-… in nerve injury-induced pain
behaviors and hyperexcitability of … diverse animal models of neuropathic pain suggests that …

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

K Inoue, M Tsuda - Nature Reviews Neuroscience, 2018 - nature.com
… the concept of 'microgliopathic pain' (dysfunctional-microglia-derived pain in the absence of
… have revealed that microglia are also activated in the brain in neuropathic pain, contributing …

Microglial regulation of neuropathic pain

M Tsuda, T Masuda, H Tozaki-Saitoh… - Journal of pharmacological …, 2013 - Elsevier
… utilizing diverse animal models of neuropathic painmicroglia in neuropathic pain.
Pharmacological, molecular and genetic manipulations of the function or expression of these …

Microglia-neuron interactions in the models of neuropathic pain

H Tozaki-Saitoh, M Tsuda - Biochemical pharmacology, 2019 - Elsevier
neuropathic pain exist in the activated microglia, but the factors driving pain-inducible microglial
… Therefore, to find the key molecules inducing activation of spinal microglia and to figure …

Microglia in the spinal cord and neuropathic pain

M Tsuda - Journal of diabetes investigation, 2016 - Wiley Online Library
… from diverse animal models of neuropathic pain … of microglia in neuropathic pain caused
by PNI and diabetes. A model of mechanisms underlying microglia-mediated neuropathic pain

P2X4R+ microglia drive neuropathic pain

S Beggs, T Trang, MW Salter - Nature neuroscience, 2012 - nature.com
… There are several potential responsive phenotypes, reflecting the functional diversity of
reactive microglia to diverse pathologies, such that they can mediate both neuroprotective and …

Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain

K Popiolek-Barczyk, J Mika - Current Medicinal Chemistry, 2016 - ingentaconnect.com
… The diverse forms of microglial cell activation and the associated inflammatory responses
have been suggested to be new targets for the development of an effective therapy against the …

Microglia-mediated regulation of neuropathic pain: molecular and cellular mechanisms

M Tsuda - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
diverse models of neuropathic pain. However, the contribution of microglial P2X4R in
neuropathic pain … A sex difference in the role of microglial molecules in neuropathic pain was also …

Microglia: sculptors of neuropathic pain?

H Ward, SJ West - Royal Society open science, 2020 - royalsocietypublishing.org
… for diversemicroglial mechanisms in driving neuropathic pain states [13–16], and critically
analyse important insights relating structural changes of neuronal circuitry to the neuropathic