… These results suggested that MITF regulates not only the expression of enzymes involved
in melanin synthesis, but also the expression of a receptor which plays an essential role in …

… Skin pigmentation, resulting from the production and distribution of melanin in the epidermis,
is the major physiologic defense against solar irradiation. In mammals, melanogenesis is …

… containing dark, brown coarse melanin pigment) were not … To identify other potential
conserved transcription factor … database (2006.1 release) using MatInspector (release 7.4; …

… We identified Microphthalmia as the affected, downregulated transcription factor in … 1M:
Po1Y1110rizal:ion orS.fi-dihydroxyindolc-2-carbox-ylic a~id ro melanin by the Pl1lel 17 sih'cr …

… stimulated microphthalmia-associated transcription factor … levels of microphthalmia-associated
transcription factor expression … dramatic increases in melanin production by melanoblasts. …

… melanin synthesis, and following uv irradiation. We therefore analyzed its effects on melanin
… was preceded by a decrease in microphthalmia transcription factor (Mitf) gene expression, …

… melanin formation under basal conditions and after α-MSH stimulation, demonstrating that
constitutive or stimulated Nox4-dependent ROS inhibits melanin … -stimulated ROS release was …

… zipper transcription factor MITF binds to E-box sequence in promoter region of genes coding
for melanin synthesis, … These are the enzymes to convert colorless l-dopa into melanin ( …

… the production of melanin. We hypothesize that increased melanin production may be …
Mitf is a melanocyte-specific transcription factor, and controls pigmentation by regulating the …

… deaf animals lacking melanocytes with severe microphthalmia and osteopetrosis (reviewed
in 32 … photography is dependent on the presence of melanin in both RPE cells and choroidal …