… The TFEC cDNA isolated from humans (TFECL) contains the activation domain corresponding
to AD1 in Mitf and is a modest transactivator (226). The functions of these different Tfec …

… box-spe cific basal activity is seen in 3T3 cells as well as strong Mispecific trans-activation. …
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but …

… with a member of LEF-1/TCF transcription factors, containing a high-mobility group domain.
Thus, LEF-1/TCF transcription factors mediate a nuclear response to Wnt signals. We have …

… Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key
role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, …

… domain of Lef1 and two different transactivation domains derived from either the C
terminus of β-catenin ( Fig. 5A , LEFΔN-βCTA) or the VP16 protein ( Fig. 5A , LEFΔN-VP16) (Citation…

… regulated by Mi and provides insight into the ability of bHLH-LZ transcription factors to
achieve the specificity required for the precise coordination of transcription during development. …

… that transactivating effects of … transcription factors. This repression was due to direct
protein/protein interactions involving both Pax-6 DNA-binding domains and the Mitf b-HLH-LZ …

… The microphthalmia (MiT) family of transcription factors comprises four distinctly encoded …
in their DNA-contacting basic domains and the transactivation domains, recognize similar DNA …

… a domain of LEF‐1 that is required for transactivation of … domain (amino acid residues 2–37)
(Behrens et al., 1996; Molenaar and van de Wetering, 1996). The degree of transactivation …

… helix-loop-helix leucine zipper (Zip) domain of MITF, resulted in the isolation of the STAT3
… in suppressing the transcriptional activity of MITF. Here, we report that the Zip domain is the …