Integrated combination treatment using a “smart” chemotherapy and microRNA delivery system improves outcomes in an orthotopic colorectal cancer model

HJ Liu, X Luan, HY Feng, X Dong… - Advanced Functional …, 2018 - Wiley Online Library
… , we present a MSN delivery system codelivery of DOX and a nucleic acid (miRNA-145) (…
via a reduction-sensitive disulfide linkage, for miRNA condensation. The woven PEI on the MSN …

Strategies to modulate microRNA functions for the treatment of cancer or organ injury

TJ Lee, X Yuan, K Kerr, JY Yoo, DH Kim, B Kaur… - Pharmacological …, 2020 - ASPET
… inhibitors and highlights current progress in miRNA-… in miRNA delivery, we believe that
additional therapeutic approaches to modulate miRNA function will soon enter routine medical

Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine

C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
… are in commercial space as future medicines. This review summarizes the patents of miRNA-
and siRNA-… of miRNA and siRNA molecules. An insightful view about individual siRNA and …

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer

EA Orellana, S Tenneti, L Rangasamy… - … translational medicine, 2017 - science.org
… of microRNA replacement is limited by deficient delivery vehicles. In this work, microRNAs
are delivered in … of microRNAs to folate (FolamiR), which mediates delivery of the conjugated …

microRNAs as novel therapeutics in cancer

G Romano, M Acunzo, P Nana-Sinkam - Cancers, 2021 - mdpi.com
… There is a dedicated focus on the different methods available for microRNA deliverydelivery
methods. Finally, we discuss the ongoing clinical trials that are using microRNAs for cancer

Nanoparticle-based delivery of tumor suppressor microRNA for cancer therapy

CP O'Neill, RM Dwyer - Cells, 2020 - mdpi.com
… MiR-34a encapsulated in a liposomal formulation, coined MRX34, was tested as a viable TS
miRNA delivery therapy in a preclinical liver cancer study. After IV injection of MRX34 in two …

MicroRNA and cancer

W Wu - Methods Mol Biol, 2011 - Springer
cancer-associated miRNAs are proving worthwhile as effective cancer biomarkers for individualized
medicine … the first edition of our book about “microRNA and cancer,” it has become a …

[HTML][HTML] MicroRNA as tools and therapeutics in lung cancer

JF Barger, SP Nana-Sinkam - Respiratory medicine, 2015 - Elsevier
miRNA (pri-miRNA), processed by the ribonuclease Drosha into a precursor hairpin (pre-miRNA
the nucleus where they are cleaved by Dicer generating mature miRNA [7], [8]. They are …

Therapeutic use of microRNAs in lung cancer

O Fortunato, M Boeri, C Verri, M Moro… - BioMed research …, 2014 - Wiley Online Library
… In summary, this study provided evidence for the safe and effective therapeutic delivery of a
miRNA mimics. However, further studies have to demonstrate that miRNAs replacement has …

[HTML][HTML] MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine

B Smith, P Agarwal, NA Bhowmick - Endocrine-related cancer, 2017 - ncbi.nlm.nih.gov
… prevailing precision medicine initiative and the capabilities of microRNA to … However, prostate,
ovarian and breast cancers are … of these cancers by regulating microRNAs. Reciprocally, …