Integrated combination treatment using a “smart” chemotherapy and microRNA delivery system improves outcomes in an orthotopic colorectal cancer model
… , we present a MSN delivery system codelivery of DOX and a nucleic acid (miRNA-145) (…
via a reduction-sensitive disulfide linkage, for miRNA condensation. The woven PEI on the MSN …
via a reduction-sensitive disulfide linkage, for miRNA condensation. The woven PEI on the MSN …
Strategies to modulate microRNA functions for the treatment of cancer or organ injury
… inhibitors and highlights current progress in miRNA-… in miRNA delivery, we believe that
additional therapeutic approaches to modulate miRNA function will soon enter routine medical …
additional therapeutic approaches to modulate miRNA function will soon enter routine medical …
Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine
C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
… are in commercial space as future medicines. This review summarizes the patents of miRNA-
and siRNA-… of miRNA and siRNA molecules. An insightful view about individual siRNA and …
and siRNA-… of miRNA and siRNA molecules. An insightful view about individual siRNA and …
FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
… of microRNA replacement is limited by deficient delivery vehicles. In this work, microRNAs
are delivered in … of microRNAs to folate (FolamiR), which mediates delivery of the conjugated …
are delivered in … of microRNAs to folate (FolamiR), which mediates delivery of the conjugated …
microRNAs as novel therapeutics in cancer
… There is a dedicated focus on the different methods available for microRNA delivery … delivery
methods. Finally, we discuss the ongoing clinical trials that are using microRNAs for cancer …
methods. Finally, we discuss the ongoing clinical trials that are using microRNAs for cancer …
Nanoparticle-based delivery of tumor suppressor microRNA for cancer therapy
CP O'Neill, RM Dwyer - Cells, 2020 - mdpi.com
… MiR-34a encapsulated in a liposomal formulation, coined MRX34, was tested as a viable TS
miRNA delivery therapy in a preclinical liver cancer study. After IV injection of MRX34 in two …
miRNA delivery therapy in a preclinical liver cancer study. After IV injection of MRX34 in two …
MicroRNA and cancer
W Wu - Methods Mol Biol, 2011 - Springer
… cancer-associated miRNAs are proving worthwhile as effective cancer biomarkers for individualized
medicine … the first edition of our book about “microRNA and cancer,” it has become a …
medicine … the first edition of our book about “microRNA and cancer,” it has become a …
[HTML][HTML] MicroRNA as tools and therapeutics in lung cancer
JF Barger, SP Nana-Sinkam - Respiratory medicine, 2015 - Elsevier
… miRNA (pri-miRNA), processed by the ribonuclease Drosha into a precursor hairpin (pre-miRNA…
the nucleus where they are cleaved by Dicer generating mature miRNA [7], [8]. They are …
the nucleus where they are cleaved by Dicer generating mature miRNA [7], [8]. They are …
Therapeutic use of microRNAs in lung cancer
… In summary, this study provided evidence for the safe and effective therapeutic delivery of a
miRNA mimics. However, further studies have to demonstrate that miRNAs replacement has …
miRNA mimics. However, further studies have to demonstrate that miRNAs replacement has …
[HTML][HTML] MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine
B Smith, P Agarwal, NA Bhowmick - Endocrine-related cancer, 2017 - ncbi.nlm.nih.gov
… prevailing precision medicine initiative and the capabilities of microRNA to … However, prostate,
ovarian and breast cancers are … of these cancers by regulating microRNAs. Reciprocally, …
ovarian and breast cancers are … of these cancers by regulating microRNAs. Reciprocally, …