… microRNA, microRNA site, or mRNA—including the mRNA sequence around the site—to
predict which sites within mRNAs are most effectively targeted by microRNAs. … effective target …

… number of preferentially conserved miRNA target sites. The new … In total, >45,000 miRNA
target sites within human 3′UTRs are … under selective pressure to maintain pairing to miRNAs. …

… Each highly conserved mammalian miRNA typically targets mRNAs of … to a target is extensive,
a miRNA can direct destruction of the targeted mRNA through Argonaute-catalysed mRNA …

… However, the mRNAs regulated by vertebrate miRNAs are … that predicts hundreds of
mammalian miRNA targets and provide … fundamental questions about miRNA:target relationships …

… ) in excess to target mRNAs or those miRNAs that dissociated from their target mRNAs
during isolation. Evidence showing that the polyribosome-associated miRNA target mRNAs are …

… for the localization of most miRNA target sites in noncoding regions of mRNAs in mammals.
… a functional basis for the observed distribution of miRNA target sites in mammalian systems. …

… the course of vertebrate and mammalian evolution (Huntley et al. 2006). To understand the
role that these duplications played in forming miRNA targets sets, we collected sequences of …

… (3) We assessed the enrichment of miRNA targets in mRNAs that are known cargoes of
FMRP, an RNA-binding protein known to be involved in translational regulation. …

… prediction tools Targetscan, miRanda and PicTar search for miRNA targets exclusively in
mRNA 3′-UTRs and do not incorporate evidence of functional targeting within the 5′-UTR …

… function is still extremely limited, but it may be that by integrating mRNA and miRNA sequence
and expression data with other comparative genomic data, we will be able to gain global …