… The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a
small but significant proportion of colorectal cancers. While MSI is identified in most cancers in …

… Stratifying cancer patients with defective MMRs and MSI may facilitate individualized therapy.
Accordingly, diagnostic characterization of MSI status has implications in clinical oncology …

… the diversity of colorectal cancers and implications for specialized management of patients.
… tumor is caused by the hypermutable phenotype known as microsatellite instability (MSI). …

… Sporadic tumors typically occur in older female patients, whereas, CRC in the context of
LS often occurs in younger patients (50 years of age or less). Finally, CRCs with MSI have a …

… high-frequency microsatellite instability in 17 percent of colorectal-cancer specimens from
a population-based series of relatively young patients. In most of these patients, there was no …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It … More data are needed to determine how best to treat patients with …

… [36] clarified that between high-level microsatellite instability colorectal cancer patients,
compared with MSS tumors, tumors are infiltrated with dense cytotoxic T cells. The study of Nouri …

… instability, and of these, about 1 in 5 (2%–4% overall) are … condition predisposing the patient
to cancers of multiple organ … literature on microsatellite instability in colorectal cancer and …

… In univariate analysis, we found a significant survival advantage for MSI-H colorectal
cancer patients who were carriers of MMR gene mutations as compared with those who were …

… To the contrary, although the numbers were small, one retrospective study suggested that
stage III colon cancer patients with deficient MMR may have improved outcomes when treated …