… glutamate release at cortical pyramidal cell synapses, we … cortical neurons from neonatal
WT and R192Q KI mice. Single cortical neurons grown on glial microislands form synaptic …

… to experimentally induced cortical spreading depression (CSD) is a key migraine-relevant …
review the synaptic alterations in the cerebral cortex of the genetic models of migraine and …

… Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is
… In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is …

… cortical glutamate neurotransmitter release 8, 9. In this study, we compared the molecular …
of cortical synapse proteomes of Cacna1a R192Q KI and wild-type (WT) mice to investigate …

… and heterozygous S218L KI mice, suggesting compensatory changes in the homozygous
mice. Furthermore, we reveal a unique feature of S218L KI cortical synapses which is the …

… mouse models supports the view of migraine as a disorder of brain excitability characterized
by deficient regulation of the cortical … FS synapses was not altered in R192Q knockin mice, …

… This predicts that at such synapses Ca v 2.1 channels that open more readily and at lower
… (NMJ), a single synapse that shares with many central synapses the location of Ca V 2.1 …

… migraine onset and susceptibility to cortical spreading depression, the neurophysiological
correlate of migraine … the functional analysis of familial hemiplegic migraine mouse models. …

… for enhanced CSD susceptibility in hemiplegic migraine. Abnormal synaptic Ca 2+ homeostasis
and … Migraine is the most common neurological condition, with a prevalence of ∼15%.1 …

… from the synaptic cleft, we hypothesize that CSD facilitation in the FHM2 mouse model is
sustained by inefficient glutamate clearance by astrocytes and consequent increased cortical …