Mouse models of familial hemiplegic migraine for studying migraine pathophysiology
A Dehghani, H Karatas - Current neuropharmacology, 2019 - ingentaconnect.com
… mice and focus on how they can be used to investigate the pathophysiology of migraine,
including synaptic … the releasable pool of neurotransmitters at cortical synapses [16]. However, …
including synaptic … the releasable pool of neurotransmitters at cortical synapses [16]. However, …
Migraine pathophysiology: lessons from mouse models and human genetics
MD Ferrari, RR Klever, GM Terwindt, C Ayata… - The Lancet …, 2015 - thelancet.com
… glutamatergic neurotransmission, synaptic function, pain … mice modulated cortical spreading
depression susceptibility in much the same way that hormonal fluctuations affect migraine …
depression susceptibility in much the same way that hormonal fluctuations affect migraine …
[HTML][HTML] Arc-mediated synaptic plasticity regulates cognitive function in a migraine mouse model
L Hu, Q Gong, Y Zhou, Y Wang, T Qiu, Y Fang… - Brain Sciences, 2023 - mdpi.com
… expression in the cortex and hippocampus in migraine mice, especially in the hippocampal
CA1 and DG regions, where there are numerous pyramidal cells and synaptic connections. It …
CA1 and DG regions, where there are numerous pyramidal cells and synaptic connections. It …
[HTML][HTML] Cortical spreading depression causes unique dysregulation of inflammatory pathways in a transgenic mouse model of migraine
… changes in the cortex of wild-type (WT) and FHM1 R192Q mice that were subjected to … mice
compared with WT mice, in order to further our understanding on the role of CSD in migraine …
compared with WT mice, in order to further our understanding on the role of CSD in migraine …
Initiation of spreading depression by synaptic and network hyperactivity: Insights into trigger mechanisms of migraine aura
LV Vinogradova - Cephalalgia, 2018 - journals.sagepub.com
… Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with
enhanced excitatory transmission in Ca V 2.1 knockin migraine mice. Neurobiol Dis 2014; 69: …
enhanced excitatory transmission in Ca V 2.1 knockin migraine mice. Neurobiol Dis 2014; 69: …
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2
C Capuani, M Melone, A Tottene, L Bragina… - EMBO Molecular …, 2016 - embopress.org
… of cortical spreading depression (CSD) in a genetic mouse model of FHM2 uncovers
insights into migraine … in the vicinity of cortical glutamatergic synapses in W887R/+ KI mice. …
insights into migraine … in the vicinity of cortical glutamatergic synapses in W887R/+ KI mice. …
Pathophysiology of migraine
D Pietrobon, MA Moskowitz - Annual review of physiology, 2013 - annualreviews.org
… The analysis of cortical synaptic transmission in FHM1 knockin mice revealed a very … a key
migraine trigger. In fact, the FHM mouse models show enhanced cortical excitatory synaptic …
migraine trigger. In fact, the FHM mouse models show enhanced cortical excitatory synaptic …
Ion channels in migraine disorders
D Pietrobon - Current Opinion in Physiology, 2018 - Elsevier
… mice carrying the Ca V 2.1 channel mutation R192Q, which causes typical FHM attacks in
humans [20], and on the insights into migraine … of cortical synaptic transmission in R192Q mice …
humans [20], and on the insights into migraine … of cortical synaptic transmission in R192Q mice …
[HTML][HTML] Non-canonical glutamate signaling in a genetic model of migraine with aura
PD Parker, P Suryavanshi, M Melone… - Neuron, 2021 - cell.com
… that awake mice carrying a familial hemiplegic migraine type … of inefficient clearance following
synaptic release. Importantly, … by cortical astrocytes in familial hemiplegic migraine type 2. …
synaptic release. Importantly, … by cortical astrocytes in familial hemiplegic migraine type 2. …
[HTML][HTML] Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels
O Chever, S Zerimech, P Scalmani… - The Journal of …, 2021 - Am Soc Clin Investig
… Further, we tested blockers of neuronal excitability or synaptic transmission. The Na + …
For optogenetic experiments, we illuminated the somatosensory cortex of VGAT-ChR2 mice …
For optogenetic experiments, we illuminated the somatosensory cortex of VGAT-ChR2 mice …