… Cortical spreading depression (CSD) is a slowly propagating … to synaptic plasticity revealed
by migraine mutations in the P/… -in mice: implications for basic mechanisms of migraine pain. …

… It has been demonstrated that R192Q KI mice have enhanced cortical excitatory synaptic …
synapses. In striking contrast, inhibitory synaptic transmission at fast spiking (FS) interneurons …

… Here, we have shown that transgenic mice expressing … in the occipital cortex of patients with
visual migraine aura. It is … of neurotransmitter release in excitatory synapses (7). An analysis …

… , 2004) was caused by increased cortical glutamatergic neurotransmission (… migraine-relevant
readout for stress-induced changes in cortical hyperexcitability in the FHM1 R192Q mouse …

… Although it is impossible to measure headache in mice, the … , so we could infer that headache
occurred in mice after CSD. … and that there are synaptic connections between the activated …

… excitatory synapses suggest that the human and mouse Cav2.… In particular, cortical
glutamatergic synapses appear as key … synaptic transmission in FHM and other migraine …

… Mouse sensory barrel cortex was stimulated contralateral to the craniotomy, in the ramus
infraorbitalis of the trigeminal nerve by a set of custom-made bipolar electrodes inserted …

… synaptic activity that can be evoked by simultaneous depolarization of a minimum volume of
brain tissue, such as in cortical trauma, cerebral ischemia, or after direct cortical … mutant mice…

… indicated that delayed electrophysiological recovery of cortical synaptic function was not
the cause of prolonged and severe unilateral motor deficits after CSD in FHM1 mutant mice. …

… in the blood, cerebrospinal fluid, occipital cortex, and thalamus of migraine patients [30].
MGluR5, the … In addition, NMDA-mediated LTP deficit in mGluR5-deficient mice was rescued by …