… in the function of inhibitory interneurons contributes to glutamate‐associated central sensitization through GABABR2‐SynCAM1 signaling in chronic migraine rats

X Zeng, Y Niu, G Qin, D Zhang, J Zhou… - The FASEB …, 2020 - Wiley Online Library
… and SynCAM1 in terms of excitatory synaptic transmission, we hypothesized that a
decline in … and network disinhibition in mouse prefrontal cortex. Cereb Cortex. 2015;25:1290-1296. …

Modelling headache and migraine and its pharmacological manipulation

SE Erdener, T Dalkara - British Journal of Pharmacology, 2014 - Wiley Online Library
… of cortical spreading depolarization (CSD) during migraine … Additionally, a mono-synaptic
reflex arc between the TCC … in two families with migraine, a mouse model carrying the T44A …

Familial hemiplegic migraine type-1 mutated cav2. 1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice

CG Inchauspe, N Pilati, MN Di Guilmi, FJ Urbano… - Hearing Research, 2015 - Elsevier
… neurotransmission onto LSO synapses is opposite to that in cortical synapses. Excitatory …
) interneurons in cortical slices of the somatosensory cortex of WT and KI mouse cortical slices …

Therapeutic implications of cortical spreading depression models in migraine

T Takizawa, C Ayata, SP Chen - Progress in Brain Research, 2020 - Elsevier
… the frequency was higher in TgNotch3 R90C mice compared to that in WT mice. Notch3 −/− …
metabolic stresses to synapses and common triggers of migraine. Sleep deprivation and …

Cortical mechanisms of single-pulse transcranial magnetic stimulation in migraine

JO Lloyd, KI Chisholm, B Oehle, MG Jones, BN Okine… - …, 2020 - Springer
… This placement over the motor cortex leads to a trans-synaptic activation of pyramidal cells
… Given that sTMS was not found to excite cortical neurons in the GCaMP mice, its influence on …

Migraine mutations impair hippocampal learning despite enhanced long-term potentiation

E Dilekoz, T Houben, K Eikermann-Haerter… - Journal of …, 2015 - Soc Neuroscience
migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in
knock-in mice … Too much plasticity would strengthen and perhaps saturate all synapses and be …

Common pathophysiologic mechanisms in migraine and epilepsy

MA Rogawski - Archives of neurology, 2008 - jamanetwork.com
… through the trigeminal ganglion and synapse on second-order … brainstem, form synapses
with neurons in the thalamus. While … of cortical hyperexcitability may characterize both migraine

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine …

SM Cain, SRA Alles, R Gopaul, LP Bernier, AC Yung… - Molecular Brain, 2023 - Springer
… vivo increased the threshold for cortical spreading depolarization in transgenic mice harboring
the clinically-… A Cacna1a knockin migraine mouse model with increased susceptibility to …

CaV2. 1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis

OD Uchitel, CG Inchauspe, FJ Urbano… - Journal of Physiology …, 2012 - Elsevier
… familial hemiplegic migraine type-1 (FHM1) have in neurotransmitter release. Transgenic mice
… in the pathogenesis of migraine, including the cerebral cortex, the trigeminal ganglia, and …

Astrocytic glutamate transporters and migraine

F Conti, D Pietrobon - Neurochemical Research, 2023 - Springer
… at cortical synapses during neuronal activity and sensory stimulation. Here we review the
migraine-… glutamate transport dysfunction in FHM2 mice and their underlying mechanisms, in …