Migraine pathophysiology: lessons from mouse models and human genetics
MD Ferrari, RR Klever, GM Terwindt, C Ayata… - The Lancet …, 2015 - thelancet.com
… In this Review we will use the term migraine when referring to both types of migraine, and
the terms migraine with aura and migraine without aura when specifically addressing …
the terms migraine with aura and migraine without aura when specifically addressing …
[HTML][HTML] Genetic mouse models of migraine
D Pietrobon, KC Brennan - The Journal of Headache and Pain, 2019 - Springer
… Mouse models of rare monogenic forms of migraine provide a unique experimental system
… a migraine disorder. Here, we discuss the migraine-relevant phenotypes and the migraine-…
… a migraine disorder. Here, we discuss the migraine-relevant phenotypes and the migraine-…
The effects of acute and preventive migraine therapies in a mouse model of chronic migraine
AF Tipton, I Tarash, B McGuire, A Charles… - …, 2016 - journals.sagepub.com
… efficacy of migraine-preventive therapies. The objective of this study was to further
characterize this mouse model of chronic migraine by testing known and novel migraine-preventive …
characterize this mouse model of chronic migraine by testing known and novel migraine-preventive …
Characterization of a novel model of chronic migraine
AA Pradhan, ML Smith, B McGuire, I Tarash, CJ Evans… - Pain, 2014 - journals.lww.com
… in mice that was reversed by the antimigraine therapy sumatriptan [ 3 ]. In addition, in a
transgenic mouse model of familial migraine, animals expressing a human migraine gene …
transgenic mouse model of familial migraine, animals expressing a human migraine gene …
[HTML][HTML] A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression
AMJM van den Maagdenberg, D Pietrobon… - Neuron, 2004 - cell.com
… migraine type 1 (FHM-1) is a Mendelian subtype of migraine … We generated a knockin mouse
model carrying the human … ; the likely mechanism for the migraine aura). Our data show that …
model carrying the human … ; the likely mechanism for the migraine aura). Our data show that …
[HTML][HTML] SCFA treatment alleviates pathological signs of migraine and related intestinal alterations in a mouse model of NTG-induced migraine
M Lanza, A Filippone, A Ardizzone, G Casili, I Paterniti… - Cells, 2021 - mdpi.com
… of migraine and correlated dysregulations in the gut environment in a mouse model of
Nitroglycerine (NTG)-induced migraine… therapies for migraine and correlated intestinal alterations. …
Nitroglycerine (NTG)-induced migraine… therapies for migraine and correlated intestinal alterations. …
[HTML][HTML] A potential preclinical migraine model: CGRP-sensitized mice
… Having established the transgenic mouse, we faced the question of how do you measure
migraine in a mouse? Of course, we cannot fully recapitulate migraine in a mouse, but we …
migraine in a mouse? Of course, we cannot fully recapitulate migraine in a mouse, but we …
Characterization of a mouse model of headache
D Huang, L Ren, CS Qiu, P Liu, J Peterson… - Pain, 2016 - journals.lww.com
… We went on to test the effects of IScap in adult female Swiss Webster mice, as more women
have migraine compared with men. Interestingly, dural application of vehicle 10 minutes after …
have migraine compared with men. Interestingly, dural application of vehicle 10 minutes after …
[HTML][HTML] Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2
L Leo, L Gherardini, V Barone, M De Fusco… - PLoS …, 2011 - journals.plos.org
… that CSD facilitation in the FHM2 mouse model is sustained by inefficient glutamate clearance
by … of CSD in mouse models further support the role of CSD as a key migraine trigger. …
by … of CSD in mouse models further support the role of CSD as a key migraine trigger. …
Modelling headache and migraine and its pharmacological manipulation
SE Erdener, T Dalkara - British Journal of Pharmacology, 2014 - Wiley Online Library
… Based on identification of a missense mutation in the casein kinase Iδ gene in two families
with migraine, a mouse model carrying the T44A mutation has also been investigated. The …
with migraine, a mouse model carrying the T44A mutation has also been investigated. The …