… The therapeutic use of SSRIs in the treatment of both depression and migraine … , mutations
detected in familial cases of migraine and polymorphisms creating susceptibility to depression …

… migraine type 1 (FHM-1) is an autosomal-dominant subtype of migraine with aura, caused by
missense mutations … FHM-1 mutation R192Q to study the consequences of this mutation in …

… depression (CSD) in R192Q KI mice. It, however, remains unknown how other FHM1 mutations
affect cortical synaptic … from KI mice carrying the S218L mutation, which causes a severe …

… depression (CSD) is a key migraine-relevant phenotype common to the five models. Second,
we review the synaptic … Thus far there are five monogenic migraine mutations that have …

… Such models will also allow evaluating the consequences of FHM-1 mutations on
mechanisms involved in migraine, such as neurotransmission and cortical spreading depression. …

… dysfunction, namely increased calcium influx into presynaptic terminals via mutated P/Q type
calcium channels and enhanced synaptic release of glutamate, promote the initiation of SD. …

… migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by
mutations in … Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘…

… channel mutations may similarly render the migraine brain … not only for the genesis of migraine
but also for the hypoxic … progression of migraine aura and cortical spreading depression (…

… mice carrying a Ca V 2.1 mutation causing FHM, and the … depression (CSD), the phenomenon
that underlies migraine aura … Congruently, short-term synaptic depression during trains of …

… demonstrated by rare migraine disorders caused by mutations in single … of migraine patients
with comorbid depression, migraine may be a symptom or consequence of the depression. …