… than in lean hypertensive rats. In a recent investigation to identify the mechanism of the
salt-… signaling cross-talk between Rac1 and mineralocorticoid receptor (MR), an alternative …

… Sodium transport in epithelial tissues is regulated by the physiological mineralocorticoid
aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor (MR), …

… to salt-loaded rats has been shown to be followed by hypertension, cardiac hypertrophy
and … the mechanism of action of salt loading in this model of mineralocorticoid hypertension. …

… in the pathogenetic mechanisms of both mineralocorticoid-induced hypertension (MH) and
… found that mineralocorticoids (MC) can act directly on arterial wall by means of a receptor-…

… In conclusion, inflammation is a key mechanism mediating the detrimental effects of
aldosterone in the cardiovascular system. MR in endothelial cells determines leukocyte adhesion …

… experience may be worthwhile is that of the mechanism of antagonist action. It is assumed
… shown to be remarkably renoprotective in diabetic hypertensive patients (A. Sato, personal …

… syndrome, and apparent mineralocorticoid excess, which have provided new insights into
mineralocorticoid hormone action. Many patients with mineralocorticoid-based hypertension …

… One possible mechanism is through the agency of the … used in resistant hypertension and
low-renin hypertension (and … potent hypotensive in essential hypertensives with normal plasma …

… the mechanisms leading to hypertension represents an … mineralocorticoid receptor (MR),
a steroidal nuclear receptor … spironolactone, a mineralocorticoid receptor antagonist (MRA…

… the pathological role of the MR in the CV system and the major mechanisms underlying it. …
The mineralocorticoid receptor (MR) is a transcription factor of the family of steroid receptors. …