Neuroinflammation, immune system and Alzheimer disease: searching for the missing link

F Guerriero, C Sgarlata, M Francis, N Maurizi… - Aging clinical and …, 2017 - Springer
Due to an increasingly aging population, Alzheimer disease (AD) represents a crucial issue
for the healthcare system because of its widespread prevalence and the burden of its care …

[HTML][HTML] Plasma aβ: a possible missing link between Alzheimer disease and diabetes

N Sato, R Morishita - Diabetes, 2013 - ncbi.nlm.nih.gov
… interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic
… hypothalamus and adjoining areas of Alzheimer’s disease patients: amorphic plaques and …

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease

A Grimm, K Friedland, A Eckert - Biogerontology, 2016 - Springer
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that represents the
most … Thus, mitochondrial dysfunction may represent the missing link between aging and …

Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential

N Sato, S Takeda, K Uchio-Yamada… - Current aging …, 2011 - ingentaconnect.com
Diabetes mellitus (DM) is one of the major non-genetic risk factors for Alzheimer disease (AD).
However, the mechanism by which DM increases the risk of AD has not been elucidated. …

Leptin: the missing link in Alzheimer disease?

J Harvey - Clinical chemistry, 2010 - academic.oup.com
In Western societies, life expectancy is increasing steadily. As a consequence, more
individuals are suffering from age-related disorders such as Alzheimer disease (AD). 2 The …

Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis

NL Rasgon, HA Kenna - Neurobiology of aging, 2005 - Elsevier
Alzheimer's disease (AD). We previously suggested central nervous system (CNS) effects
of insulin resistance (IR) to be an important link … Herein, we review the IR link in depressive …

The missing link in the amyloid cascade of Alzheimer's disease–metal ions

A Tiiman, P Palumaa, V Tougu - Neurochemistry international, 2013 - Elsevier
Progressive deposition of amyloid beta (Aβ) peptides into amyloid plaques is the
pathological hallmark of Alzheimer’s disease (AD). The amyloid cascade hypothesis pins this …

Alzheimer's disease: from pathogenesis to mesenchymal stem cell therapy–bridging the missing link

J Hu, X Wang - Frontiers in cellular neuroscience, 2022 - frontiersin.org
… depending on the age of disease onset. Early onset Alzheimer’s Disease (EOAD) represents
less than 10 percent of all patients with Alzheimer’s disease. It typically occurs between a …

Biomarkers for Alzheimer's disease: Searching for the missing link between biology and clinic

M Boenink - … Technologies for Diagnosing Alzheimer's Disease …, 2016 - Springer
Boenink argues that responsible biomedical research should at least address legitimate and
urgent needs of those suffering from the disease, and asks whether research on molecular …

Neurodegeneration in Alzheimer's disease and glaucoma: overlaps and missing links

S Sen, R Saxena, M Tripathi, D Vibha, R Dhiman - Eye, 2020 - nature.com
… Other pathways such as the insulin receptor pathway also seem to be affected in both
diseases similarly. In spite of these overlaps, there are few missing links which still need more …