… to senescence and aging. We also highlight the potential of senescence-associated mitochondrial
dysfunction as … converging onto mitochondrial dysfunction as novel, potent senolytics. …

… Cellular senescence and mitochondrial dysfunction have both … it is now well regarded that
cellular senescence is a key driver … Emerging evidence has pinpointed mitochondria as one of …

… cells occurs after a more or less constant number of cell divisions. Few data are available
concerning the role of mitochondria … involvement of mitochondria in replicative senescence and …

… Cellular senescence permanently arrests cell … mitochondrial perturbations induced a
similar senescent phenotype, which we term mitochondrial dysfunction-associated senescence (…

… of cellular senescence, the theory has been extended to mitochondrial oxidative stress
theory [27]. Although there has been extensive research, the theory of senescence free radicals/…

… , cellular senescence and mitochondrial dysfunction would result in tissue or organ degeneration
and dysfunction … mechanisms of cellular senescence, mitochondrial malfunction and …

… For instance, endothelial cell senescence was shown to be induced by endogenous
NADPH oxidase NOX4 [[87]], which in turn can contribute to mitochondrial dysfunction by …

… , since the effects of mitochondrial dysfunction can activate the p53 and Rb pathways,
generating positive feedback mechanisms that we propose contribute to keeping cells senescent. …

… ages and the amount of intracellular NAD+ decline during aging, the reduced activity of
Sirt1 could lead to the decision to cell senescence or apoptosis instead of cellular survival [101, …

… aging, senescence, and cellular dysfunction in PLHIV. This … between mitochondrial
compromise and cellular dysfunction … impact mitochondrial functions and contribute to cellular …