… Recently, we provided genetic basis showing that mitochondrial dysfunction can trigger motor
neuron degeneration, through identification of CHCHD10 encoding a mitochondrial protein…

… in mitochondria within the motoneurons impact aging muscle is less evolved. Indeed, most
of our understanding in the context of mitochondrial … junction degeneration, mitochondrial …

… To further explore the negative influence of muscle mitochondrial uncoupling on motor
neuron degeneration, we analysed whether muscle UCP1 overexpression could change the …

… Despite the increase in content, the function of mitochondria is … induced NMJ degeneration
and mitochondrial dysfunction are … -induced NMJ degeneration and mitochondrial dysfunction …

… A wide variety of mitochondrial DNA (mtDNA) mutations have recently been identified in
degenerative diseases of the brain, … It has the same breakpoint junction as the 6.1 kb insertion. …

… Whatever the mechanisms our results support the hypothesis that mitochondrial dysfunction
and early degeneration of the NMJ is a convergent event in the pathogenesis of ALS (26,28,…

… Neurons have a high demand for mitochondrial metabolism and contain many mitochondria
throughout the cytoplasm. In neurons and many other cell types mitochondria are …

… the narrow junctional regions that insulate the mitochondrial … the mitochondrial network due
to unopposed mitochondrial … leads to optic nerve degeneration and subsequent visual failure…

… synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in
… The purpose of this study was to better understand the effects of Aβ in mitochondrial activity …

… from a spermatid individualization defect at a late stage of spermatogenesis. Mitochondrial
pathology is the earliest manifestation of muscle degeneration and a prominent characteristic …