… associated with mitochondrial destabilization may critically activate the NLRP3
inflammasome. … step to trigger mitochondrial destabilization, generating the mitochondrion-associated …

… mechanisms by which mitochondria regulate NLRP3 inflammasome activation. … Mitochondrial
destabilization caused by NLRP3 activators does not activate the NLRP3 inflammasome …

… the central role of mitochondria in the activation of the NLRP3 inflammasome. These studies
… how both mitochondrial dysfunction and gain-of-function mutations in NLRP3 can result in …

… are required for NLRP3 inflammasome activation triggered by … NLRP3 activators cause
mitochondrial destabilization and … lysosomal destabilization for triggering NLRP3 inflammasome …

… NLRP3 inflammasome through mitochondrial proteins, such as MAVS or Mfn2, and the
mitochondrial … The molecular details for how lysosomal destabilization or lysosomotrophic agents …

… MAVS mediates recruitment of NLRP3 to mitochondria, promoting production of IL-1β …
NLRP3 inflammasome in vivo. Our data support a more complex model of NLRP3 inflammasome …

… NLRP3 inflammasome activation. In this connection, mitophagy-mediated maintenance of
mitochondrial homeostasis restricts NLRP3 inflammasome … mitochondrial destabilization and …

… dysregulation, ATP, cholesterol, uric acid, and amyloid β, which result in the release of ROS,
as well as lysosomal enzyme cathepsins B or L and Ca 2+ caused by destabilization and …

… We recently showed that TXNIP is found in mitochondria and causes mitochondrial
dysfunction in retinal cells under high glucose enviromnent [6]. Removal or segregation of the …

… localization have all been implicated in regulating NLRP3 activity. In this article we … of NLRP3
inflammasome activation, and highlight other recent contentious issues concerning NLRP3 …