Mitochondrial dysfunction in diabetic kidney disease

JM Forbes, DR Thorburn - Nature Reviews Nephrology, 2018 - nature.com
diabetic kidney disease (DKD) remain to be fully elucidated. Mitochondrial dysfunction is
associated with kidney disease … suggests that dysfunctional renal mitochondria are pathological …

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

GC Higgins, MT Coughlan - British journal of pharmacology, 2014 - Wiley Online Library
mitochondrial dysfunction can lead to intrinsic cell death. Ultimately, the question of whether
mitochondrial dysfunction is … Without healthy mitochondria, cellular homeostasis within the …

Mitochondrial dysfunction in diabetic kidney disease

PZ Wei, CC Szeto - Clinica Chimica Acta, 2019 - Elsevier
… Although diabetic kidney disease (DKD) is the most common cause of end-stage … to
mitochondrial dysfunction. Mitochondrial dysfunction contributes to the progression of chronic …

Mitochondrial dysfunction and diabetic nephropathy: nontraditional therapeutic opportunities

PN Zhang, MQ Zhou, J Guo, HJ Zheng… - Journal of Diabetes …, 2021 - Wiley Online Library
diabetic complication. Growing evidence shows that persistent mitochondrial dysfunction
contributes to the progression of renal diseases, including DN, as it alters mitochondrial

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy

S Saxena, A Mathur, P Kakkar - Journal of cellular physiology, 2019 - Wiley Online Library
… Impaired mitochondrial function and their aberrant accumulation have been known to …
diabetic nephropathy, indicating perturbed balance of mitochondrial dynamics, and mitochondrial

Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy

S Sifuentes-Franco, DE Padilla-Tejeda… - International journal …, 2018 - Wiley Online Library
… However, when mitochondrial dysfunction exists, or in the state of persistent hyperglycemia,
… Q and complex III, since the mitochondrial respiratory chain is the primary source in the …

Glomerular endothelial mitochondrial dysfunction is essential and characteristic of diabetic kidney disease susceptibility

H Qi, G Casalena, S Shi, L Yu, K Ebefors, Y Sun… - Diabetes, 2017 - Am Diabetes Assoc
The molecular signaling mechanisms between glomerular cell types during initiation/progression
of diabetic kidney disease (DKD) remain poorly understood. We compared the early …

[HTML][HTML] Mitochondrial dysfunction in diabetic tubulopathy

L Yao, X Liang, Y Qiao, B Chen, P Wang, Z Liu - Metabolism, 2022 - Elsevier
Diabetic kidney disease (DKD) is a devastating microvascular complication associated with
… of mitochondrial dysfunction may accelerate initiation of early-stage diabetic tubulopathy, as …

Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease

K Sharma, B Karl, AV Mathew, JA Gangoiti… - Journal of the …, 2013 - journals.lww.com
… are linked to mitochondrial metabolism and … of mitochondrial activity in diabetic kidney
disease. Supporting this analysis, human diabetic kidney sections expressed less mitochondrial

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy

J Sun, H Zhu, X Wang, Q Gao, Z Li… - Journal of …, 2019 - joe.bioscientifica.com
… Among several theories linking mitochondrial dysfunction to DN, the mitochondrial … could
play a role in mitochondrial dysfunction. We first assessed the mGECs mitochondrial OCR. A …