… underlies the pathogenesis of neurodegenerative diseases then a reasonable therapeutic
strategy is to utilize compounds which improve mitochondrial function. Coenzyme Q 10 or …

… Mitochondria function in the regulation of cytoplasmic Ca 2 + levels. Utilizing specific transport
systems, these organelles can move Ca 2 + from the cytosol into their matrix by the Ca 2 + …

… directly involved in mitochondrial functions, such as SURF1, frataxin, and paraplegin. …
diseases that are not due to primary mitochondrial abnormalities. In these cases, the mitochondrial …

… is to highlight the importance of mitochondria in neurodegeneration by providing an up-to-…
common neurodegenerative diseases: Alzheimer’s disease (AD) and Parkinson’s disease (PD…

… of vitamin E deficiency on mitochondrial function [64]. … encoding mitochondrial proteins
in neurodegenerative diseases … (OPA1) and Charcot Marie Tooth disease (mitofucin) [100]. …

… α-synucleinParkin Cytosolic protein that, when overexpressed or mutant, impairs
mitochondrial function and leads to oxidative stress.Ubiquitin E3 ligase that has been found to be …

… Mitochondrial metabolic decline and oxidative stress have been directly implicated in … the
neurodegenerative diseases. Moreover, different studies have shown that most of the disease-…

… Neurodegenerative diseases are a large group of disabling disorders of the nervous system,
… evidence of impaired mitochondrial function as a causative factor in these diseases. More …

… classical nuclear DNA related diseases and has turned attention to defining the role of
mitochondria in the pathogenesis of many neurodegenerative diseases, a heterogeneous group …

… The accumulation of these deletions and point mutations with ageing correlates with decline
in mitochondrial function. For example, a negative correlation has been found between …