Mitochondrial fusion, fission, and mitophagy in cardiac diseases: challenges and therapeutic opportunities
DL Scheffer, AA Garcia, L Lee… - Antioxidants & Redox …, 2022 - liebertpub.com
… mitochondrial fusion and control mitochondrial crista dynamics (7, 87). On the contrary,
stress-induced Opa1 cleavage by Oma1 results in short forms, which triggers mitochondrial …
stress-induced Opa1 cleavage by Oma1 results in short forms, which triggers mitochondrial …
[HTML][HTML] Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities
A Hernández-Aguilera, A Rull… - Mediators of …, 2013 - hindawi.com
… mitochondrial size is reduced [71]. Therefore, a detailed characterisation of the proteins
involved in mitochondrial fusion … might have a great therapeutic potential to improve metabolism …
involved in mitochondrial fusion … might have a great therapeutic potential to improve metabolism …
Mitochondrial fragmentation in liver cancer: Emerging player and promising therapeutic opportunities
Q Wang, P Yu, C Liu, X He, G Wang - Cancer Letters, 2022 - Elsevier
… fission and fusion [1]. Increased mitochondrial fission leads to mitochondrial fragmentation
(… whereas increased mitochondrial fusion leads to elongation of the mitochondrial network as …
(… whereas increased mitochondrial fusion leads to elongation of the mitochondrial network as …
[HTML][HTML] Mitochondrial dysfunction and diabetic nephropathy: nontraditional therapeutic opportunities
PN Zhang, MQ Zhou, J Guo, HJ Zheng… - Journal of Diabetes …, 2021 - hindawi.com
… Mitochondrial fusion is mainly involved in the synthesis and repair of mitochondria. When …
significance and therapeutic opportunities,” Antioxidants & Redox Signaling, vol. 12, no. 4, pp. …
significance and therapeutic opportunities,” Antioxidants & Redox Signaling, vol. 12, no. 4, pp. …
Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities
A Sarwar, M Zhu, Q Su, Z Zhu, T Yang, Y Chen… - Critical Reviews in …, 2022 - Elsevier
… , the STING1 directly binds with the MFN1/2, eventually, leading to the mitochondrial
fusion and ROS production, which results into ferroptosis without involvement of PINK1-associated …
fusion and ROS production, which results into ferroptosis without involvement of PINK1-associated …
[HTML][HTML] Mitochondrial flexibility of breast cancers: a growth advantage and a therapeutic opportunity
A Avagliano, MR Ruocco, F Aliotta, I Belviso, A Accurso… - Cells, 2019 - mdpi.com
… with its phosphorylation and translocation to mitochondria; it also enhances mitochondrial
fusion and the expression of both mitochondrial fusion and biogenesis-associated proteins, …
fusion and the expression of both mitochondrial fusion and biogenesis-associated proteins, …
Disruption of mitochondrial quality control in peripheral artery disease: new therapeutic opportunities
… role of mitochondrial bioenergetics and quality control mechanisms including mitochondrial
fusion-… in the pathophysiology of PAD, and highlight their potential as therapeutic targets. …
fusion-… in the pathophysiology of PAD, and highlight their potential as therapeutic targets. …
Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities
WI Sivitz, MA Yorek - Antioxidants & redox signaling, 2010 - liebertpub.com
… of mitochondrial uncoupling and coenzyme Q. Finally, we address the potential for targeting
mitochondria in the therapy … address the role of mitochondrial uncoupling and coenzyme Q. …
mitochondria in the therapy … address the role of mitochondrial uncoupling and coenzyme Q. …
[HTML][HTML] Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities
J Lv, Y Li, S Shi, X Xu, H Wu, B Zhang… - Biomedicine & …, 2022 - Elsevier
… mitochondrial remodeling in HF patients or animal models, including the impairments in
mitochondrial … creatine kinase (mi-CK), depressed GTPases that mediate mitochondrial fusion, …
mitochondrial … creatine kinase (mi-CK), depressed GTPases that mediate mitochondrial fusion, …
[HTML][HTML] Mitochondrial base editing: recent advances towards therapeutic opportunities
Mitochondria are critical organelles that form networks within our cells, generate energy
dynamically, contribute to diverse cell and organ function, and produce a variety of critical …
dynamically, contribute to diverse cell and organ function, and produce a variety of critical …
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