The role of reactive oxygen species in mitochondrial permeability transition

AE Vercesi, AJ Kowaltowski, MT Grijalba… - Bioscience …, 1997 - Springer
… We have provided evidence that mitochondrial membrane permeability transition induced …
by a Ca^-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at …

Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I

C Batandier, X Leverve, E Fontaine - Journal of Biological Chemistry, 2004 - ASBMB
permeability transition pore (PTP) opening on the rate of production of reactive oxygen species
in isolated rat liver mitochondria. … O 2 production when mitochondria were energized both …

Reactive oxygen species (Ros-Induced) Ros release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes

DB Zorov, CR Filburn, LO Klotz, JL Zweier… - The Journal of …, 2000 - rupress.org
… between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) …
production at sites of spontaneously deenergized mitochondria. We devised a new model …

Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast

M Carraro, P Bernardi - Cell calcium, 2016 - Elsevier
… In this short review we discuss the nature of the yeast permeability transition and reevaluate
its potential role in the effector phase of yeast PCD triggered by Ca 2+ and oxidative stress. …

Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition

MJ Hansson, R Månsson, S Morota, H Uchino… - Free Radical Biology …, 2008 - Elsevier
… subsequent increase in reactive oxygen species (ROS) … mitochondrial calcium uptake and
ROS production remain unknown but activation of the mitochondrial permeability transition (…

… mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2+ is dependent on mitochondrial‐generated reactive oxygen …

AJ Kowaltowski, RF Castilho, AE Vercesi - FEBS letters, 1996 - Wiley Online Library
… that mitochondrial membrane permeability transition in Ca2÷-loaded mitochondria treated
with … Permeability transition is prevented either by EGTA, catalase or dithiothreitol, suggesting …

Molecular mechanisms and consequences of mitochondrial permeability transition

M Bonora, C Giorgi, P Pinton - Nature reviews Molecular cell biology, 2022 - nature.com
… contributes to generation of reactive oxygen species (ROS). … mitochondrial permeability
transition pore (mPTP) opening induces the closure of the mPTP and restoration of mitochondrial

… increased respiration and generation of reactive oxygen species, resulting in ATP depletion, opening of mitochondrial permeability transition, and programmed cell …

BS Tiwari, B Belenghi, A Levine - Plant physiology, 2002 - academic.oup.com
… respiratory electron transport and oxygen uptake in isolated mitochondria, leading to … the
mitochondrial permeability transition and release of cytochromec from the inner mitochondrial

Transient opening of mitochondrial permeability transition pore by reactive oxygen species protects myocardium from ischemia-reperfusion injury

M Saotome, H Katoh, Y Yaguchi… - American Journal …, 2009 - journals.physiology.org
Reactive oxygen species (ROS) production during ischemia-reperfusion (I/R) is thought to …
whether it could mediate the mitochondrial permeability transition pore (mPTP) opening. The …

Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes

WX Ding, HM Shen, CN Ong - Hepatology, 2000 - Elsevier
… This study was designed to investigate the role of reactive oxygen species (ROS) and
mitochondrial permeability transition (MPT) in the M-LR–induced apoptotic process. Morphologic …