Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

X Li, P Fang, J Mai, ET Choi, H Wang… - Journal of hematology & …, 2013 - Springer
… how mitochondria generate and regulate the production of mtROS and the function of mtROS
both in physiological and pathological conditions. … inflammatory diseases and inflammatory

Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies

A Rimessi, M Previati, F Nigro, MR Wieckowski… - The international journal …, 2016 - Elsevier
… in the coordination of pro-inflammatory signaling from the … In this regard, mitochondrial
reactive oxygen species are emerging … by mitochondrial mechanisms, including reactive oxygen

Reactive oxygen species in metabolic and inflammatory signaling

SJ Forrester, DS Kikuchi, MS Hernandes, Q Xu… - Circulation …, 2018 - Am Heart Assoc
Mitochondrial reactive oxygen species (ROS) production. MitoROS are produced as a normal
by-product of mitochondrial respiration and metabolic enzymatic activity. Under settings of …

[PDF][PDF] Physiological roles of mitochondrial reactive oxygen species

LA Sena, NS Chandel - Molecular cell, 2012 - cell.com
… Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively
cause cellular damage and lack a physiological function. Accumulation of ROS and oxidative …

[HTML][HTML] Mitochondrial reactive oxygen species are essential for the development of psoriatic inflammation

S Mizuguchi, K Gotoh, Y Nakashima… - Frontiers in …, 2021 - frontiersin.org
inflammation. … mitochondrial reactive oxygen species (mtROS) after IMQ stimulation. Because
the inhibition of mtROS suppressed IMQ-induced DC activation and psoriatic inflammation, …

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

AC Bulua, A Simon, R Maddipati, M Pelletier… - Journal of Experimental …, 2011 - rupress.org
mitochondrial ROS as a driver of inflammation in TRAPS and potentially other autoinflammatory
diseases… role for mitochondrial ROS in the induction of inflammatory cytokines upstream …

Mitochondrial DNA and inflammatory diseases

G Escames, LC López, JA García, L Garcia-Corzo… - Human genetics, 2012 - Springer
… accompanied by mitochondrial dysfunction, which is directly involved in the cell death.
Recently, a direct implication of mitochondrial reactive oxygen species and, particularly, mtDNA in …

Mitochondrial reactive oxygen species in physiology and disease

S Antonucci, F Di Lisa, N Kaludercic - Cell Calcium, 2021 - Elsevier
Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites
within the organelle. The balance in their formation and elimination is maintained by a complex …

Mitochondrial reactive oxygen species and risk of atherosclerosis

M Hulsmans, E Van Dooren, P Holvoet - Current atherosclerosis reports, 2012 - Springer
… Mechanisms that lead to increased mitochondrial reactive oxygen species (mtROS) production.
Because the overall mtROS levels are determined by the rates of ROS generation and …

Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress

E Schulz, P Wenzel, T Münzel… - Antioxidants & redox …, 2014 - liebertpub.com
Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic
NADPH oxidase. Am J Physiol Regul Integr Comp Physiol 302: R1134–R1142, 2012. 36. …