The role of reactive-oxygen-species in microbial persistence and inflammation

R Spooner, Ö Yilmaz - International journal of molecular sciences, 2011 - mdpi.com
mitochondrion appears to be a target for microbial interference. We will now provide examples
of microbes demonstrated to modulate mitochondrial … in chronic inflammatory conditions

Mitochondrial generation of reactive oxygen species and its role in aerobic life

M Inoue, EF Sato, M Nishikawa, AM Park… - Current medicinal …, 2003 - ingentaconnect.com
… Therefore, we hypothesized that chronic inflammation might increase oxidative stress to
stimulate mitochondrial generation of ROS, thereby enhancing the mutation of mtDNA and …

Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation-A novel concept

GK Nanayakkara, H Wang, X Yang - Archives of biochemistry and …, 2019 - Elsevier
… The majority of mitochondrial reactive oxygen species are generated in the complexes I
and … for inflammatory diseases and cancers had been previously published by our lab [1]. …

Mitochondria and reactive oxygen species: physiology and pathophysiology

S Bolisetty, EA Jaimes - International journal of molecular sciences, 2013 - mdpi.com
… This review will mainly focus on the role of these reactive oxygen/nitrogen species in the …
that are regulated by reactive oxygen species (ROS) and reactive nitrogen species (RNS) and …

[HTML][HTML] TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species

FJ Roca, L Ramakrishnan - Cell, 2013 - cell.com
… TNF excess induces mitochondrial reactive oxygen species (ROS) in infected macrophages
… modulation of mitochondrial cyclophilin D, implicated in mitochondrial permeability transition …

Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

W Jing, C Liu, C Su, L Liu, P Chen, X Li… - Frontiers in …, 2023 - frontiersin.org
… Additionally, ROS and mitochondrial damage are involved in … and mitochondrial damage
on inflammatory response, … therapies that target ROS or mitochondria to relieve RA symptoms …

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation

ME Heid, PA Keyel, C Kamga, S Shiva… - The Journal of …, 2013 - journals.aai.org
… cells and may release lysosomal and mitochondrial products into the cytosol. … mitochondrial
function and decreased cellular ATP. Release of mitochondrial reactive oxygen species (…

Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C

T Wang, SA Weinman - Journal of gastroenterology and …, 2006 - Wiley Online Library
… to reactive oxygen species (ROS) generation by mechanisms that involve both mitochondria
… Hepatitis C virus (HCV) core protein localizes to both ER and mitochondria and has effects …

Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

MC Carreras, MC Franco, JG Peralta… - Molecular aspects of …, 2004 - Elsevier
mitochondria generate more reactive oxygen species, … stress is an additional factor for
mitochondrial disease (Wei et al., … and patients with mitochondrial diseases. Cybrids with MELAS (…

Mitochondrial complex II and reactive oxygen species in disease and therapy

K Hadrava Vanova, M Kraus, J Neuzil, J Rohlena - Redox Report, 2020 - Taylor & Francis
… Increasing evidence points to the respiratory Complex II (CII) as a source and modulator
of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological …