Mitochondrial dysfunction in atrial fibrillation—Mechanisms and pharmacological interventions

P Muszyński, TA Bonda - Journal of Clinical Medicine, 2021 - mdpi.com
mitochondrial welfare. This review summarizes the mechanisms of mitochondrial dysfunction
related to atrial fibrillation … targeting mitochondria to prevent or improve the outcome of atrial

Cellular and mitochondrial mechanisms of atrial fibrillation

FE Mason, JRD Pronto, K Alhussini, C Maack… - Basic research in …, 2020 - Springer
… the path towards new therapeutic targets. In this review, we discuss the importance of
mitochondrial Ca 2+ handling in regulating ATP production and mitochondrial ROS emission and …

Mitochondria and the pathophysiological mechanism of atrial fibrillation

X Li, X Yang, Y Li, M Yuan, C Tian… - Current …, 2018 - ingentaconnect.com
… in mitochondrial distribution further imply that mitochondria … between mitochondria and AF,
and provide potential therapeutic … or indirect factors that affect mitochondria function and thus …

The role of mitochondrial dysfunction in atrial fibrillation: translation to druggable target and biomarker discovery

L Pool, LFJM Wijdeveld, NMS de Groot… - International journal of …, 2021 - mdpi.com
mitochondria dysfunction in AF is presented. We highlight the key modulators of mitochondrial
… they represent potential targets for therapeutic interventions and diagnostics in clinical AF. …

Mitochondrial oxidative stress promotes atrial fibrillation

W Xie, G Santulli, SR Reiken, Q Yuan, BW Osborne… - Scientific reports, 2015 - nature.com
… the role of mitochondrial ROS in atrial RyR2 … mitochondria to decrease mitochondrial ROS
production. RyR2-S2808D +/+ /mCAT mice exhibited significantly reduced atrial mitochondrial

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review

AS Menezes Júnior, ALG França-e-Silva… - International Journal of …, 2023 - mdpi.com
… the role of mitochondrial oxidative mechanisms in AF pathophysiology, the impact of
mitochondrial oxidative stress on AF initiation and perpetuation, and current therapies. This review …

Sodium-glucose co-transporter 2 inhibition as a mitochondrial therapy for atrial fibrillation in patients with diabetes?

SR Yurista, HHW Silljé, M Rienstra, RA de Boer… - Cardiovascular …, 2020 - Springer
atrial remodelling is a hallmark of AF and the degree of atrial … In summary, mitochondrial
dysfunction in atria from diabetic … targeting mitochondria could represent a feasible therapeutic

Mitochondrial dysfunction underlies cardiomyocyte remodeling in experimental and clinical atrial fibrillation

M Wiersma, DMS van Marion, RCI Wüst… - Cells, 2019 - mdpi.com
… role of mitochondrial function in AF by measuring mitochondrial calcium … -1 atrial
cardiomyocytes induces mitochondrial Ca 2+ -handling changes, resulting in reduction in …

Mitochondrial dysfunction in atrial tissue of patients developing postoperative atrial fibrillation

J Jeganathan, R Saraf, F Mahmood, A Pal… - The Annals of thoracic …, 2017 - Elsevier
therapeutic intervention. … mitochondrial dysfunction by altering metabolic pathways, thus
leading to apoptosis and cell death. To establish this relationship, we studied the mitochondrial

Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation

KH Slagsvold, AB Johnsen, Ø Rognmo… - Physiological …, 2014 - journals.physiology.org
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a potential to cause serious
complications. Mitochondria … both mitochondrial function and the development of AF. Yet …