… ethanol metabolism links initial adaptive ethanol metabolism to mitophagy and then to
chronic maladaptive changes initiating onset and the progression of alcoholic liver disease (ALD). …

… , the mechanisms of ethanol-induced hepatic mitophagy in vivo, … dose of ethanol induced an
initial low level of hepatocyte apoptosis… in the majority of normal hepatocytes. This enhanced …

… primary site of alcohol metabolism, the liver experiences the … how alcohol consumption and
metabolism leads to mitophagy in … by ethanol metabolism to AcAld triggers Type 2 mitophagy. …

… and nutrients in hepatocytes, as an adaptive mechanism mitophagy not only … the ethanol
metabolic demand in the liver. With the aggravation of alcohol induced liver damage, mitophagy …

… for alcohol metabolism, the liver is … of mitophagy may alter from acute to chronic ethanol
exposure. Mitochondrial ROS, generated during ethanol metabolism, particularly in the liver, was …

… of damaged and dysfunctional mitochondria and subsequent liver injury, we compared levels
of mitophagy between WT and Parkin KO mice after alcohol treatment using both the acute-…

… in regulating mitophagy and mitochondrial functions to protect against alcohol-induced liver
… However, the role of mitochondrial spheroids and MDVs in alcohol-induced liver disease …

… ethanol metabolism after immediate alcohol administration, which triggers a series of mitophagy
regulating signals to promote mitophagy as … with enhanced mitophagy in hepatocytes at …

… and mitophagy in protection against alcohol-induced liver injury … -independent mechanisms
for mitophagy induction, which … alcohol metabolism occurs mainly in the liver, and alcohol is …

… AMPK can regulate mitophagy in ALD, remains unknown. Here we found that AMPK can
significantly reduce alcohol-induced liver injury and enhances hepatocytes’ mitophagy level. …