… -1 and c-Myc activity. Furthermore, we provide evidence that ERK2, and not p38 MAPK or
SAPK, mediates MKP-1 … MKP-1 may play an important role in attenuating signaling through the …

… MKP-1 is regulated is still not fully understood. Here, we show that inhibition of p38 MAP kinase
… (RNAi) markedly reduced the expression of MKP-1 in LPS or PGN-treated macrophages, …

… Our studies demonstrate that MKP-1 attenuates the activities of p38 MAPK and JNK to
regulate both pro- and anti-inflammatory cytokines in TLR signaling. These results highlight the …

… Since MAPKs can enhance MKP activities, MKPs are considered as an important feedback
… limits the MAPK cascades. This review outlines the role of MKP-1, a prototypical MKP family …

… ANP is able to induce MKP-1 in mesangial cells 45 and renal … induction of MKP-1 by ANP
results in inhibition of p38 MAPK, as … of MKP-1 in ANP-mediated p38 inhibition because MKP-1 …

… MAP kinases (MAPKs). Overexpression of MKP-1 prevented the polyglutamine-expanded
huntingtin-induced activation of c-Jun N-terminal kinases (JNKs) and p38 MAPKs, whereas …

… MKP-1 expression via activation of parallel p38 MAPK and CREB-mediated pathways and
MKP-1 serves to restrain pro-inflammatory MAPK … In this way, MKP-1 acts as a negative …

… classification of MKPs based on the sequence characteristics of their MAPK-docking site. …
that MKPs including MKP-7 have the substrate specificity toward the isoforms of the p38 MAPK …

… in C2C12 cells suppresses the activity of p38 MAPK to inhibit myogenesis. Our results show
… MKP-1, a member of the dual-specificity MAPK phosphatase, which directly inactivates p38 …

… , MKP-1, has been shown to negatively regulate p38 via dephosphorylation. We hypothesized
that MKP-1 … As activation of this MAPK correlates with phosphorylation of the protein, we …