A model of obstructive sleep apnea in normal humans: role of the upper airway

ED King, CP O'DONNELL, PL Smith… - American journal of …, 2000 - atsjournals.org
… produce pharyngeal airflow obstruction, suggesting that … obstructive sleep apnea. It is
possible that our subjects might have exhibited an even greater degree of obstructive sleep apnea

Canine model of obstructive sleep apnea: model description and preliminary application

RJ Kimoff, H Makino, RL Horner… - Journal of applied …, 1994 - journals.physiology.org
… report describes a canine model of obstructive sleep apnea (OSA) developed in our laboratory
and the results of its preliminary short-term application. Healthy adult dogs were prepared …

A predictive model for obstructive sleep apnea and Down syndrome

BG Skotko, EA Macklin, M Muselli… - American journal of …, 2017 - Wiley Online Library
… cost, the proposed model could predict which patients with DS were unlikely to have
moderate to severe obstructive sleep apnea and thus may not need a diagnostic sleep study. …

[HTML][HTML] The pathogenesis of obstructive sleep apnea

LV Pham, AR Schwartz - Journal of thoracic disease, 2015 - ncbi.nlm.nih.gov
… Finally, we consider models of periodic breathing, and … obstruction destabilizes respiratory
patterns during sleep. In our … initiation of an obstructive apnea, we will model the alterations in …

[HTML][HTML] Prediction models of obstructive sleep apnea in pregnancy: a systematic review and meta-analysis of model performance

S Siriyotha, V Tantrakul, S Plitphonganphim… - Diagnostics, 2021 - mdpi.com
obstructive sleep apnea (… models have been studied specifically during pregnancy. Methods:
A systematic review and meta-analysis were performed for multivariable prediction models

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
… the conventional obstructive sleep apnea model. The assumption that an increased apnea–…
Other factors have to be introduced into this model to enhance specificity, ie, to increase the …

Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA)

M Nácher, R Farré, JM Montserrat, M Torres, D Navajas… - Sleep medicine, 2009 - Elsevier
… In summary, in a rat model of sleep apnea we have shown that after only 3 h any one of
the tested stimuli—repetitive apneas, oxygen desaturations alone or respiratory efforts alone—…

A novel model to estimate key obstructive sleep apnea endotypes from standard polysomnography and clinical data and their contribution to obstructive sleep apnea …

R Dutta, G Delaney, B Toson, AS Jordan… - Annals of the …, 2021 - atsjournals.org
… endotypes that contribute to obstructive sleep apnea (OSA) … However, an easily interpretable
model to examine the … -defined OSA severity (ie, the apnea–hypopnea index) has not been …

Sleep architecture in a canine model of obstructive sleep apnea

RL Horner, D Brooks, LF Kozar, E Leung, H Hamrahi… - Sleep, 1998 - academic.oup.com
sleep apnea. This problem was circumvented in the present study by using a canine model
of … sleep architecture during long-term OSA with normal sleep before OSA as well as recovery …

Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea

E Belaidi, M Joyeux-Faure, C Ribuot… - Journal of the American …, 2009 - jacc.org
Objectives : Our aim was to investigate the involvement of the endothelin (ET) system in the
cardiovascular consequences of intermittent hypoxia (IH). Background : Obstructive sleep