Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure

MP Shakarjian, DE Heck, JP Gray, PJ Sinko… - Toxicological …, 2010 - academic.oup.com
… In conclusion, application of SM to pig, mouse ear, and engineered human skin graft models
reveals similar pathological sequelae and demonstrates a locus of vesication at the level of …

Therapeutic approaches to dermatotoxicity by sulfur mustard I. Modulation of sulfur mustard‐induced cutaneous injury in the mouse ear vesicant model

RP Casillas, RC Kiser, JA Truxall… - Journal of Applied …, 2000 - Wiley Online Library
… mouse ear edema model for use with sulfur mustard (HD) and used this model to study
the … in an in vivo model and support the continued use of the mouse ear vesicant model (MEVM) …

Systemic administration of candidate antivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model (MEVM)

MC Babin, K Ricketts, JP Skvorak… - Journal of Applied …, 2000 - Wiley Online Library
… to the chemical warfare agent sulfur mustard (HD). In the … h before exposure to sulfur
mustard and continuing until 24 h … animal models following cutaneous sulfur mustard exposure. …

Potential anti-inflammatory treatments against cutaneous sulfur mustard injury using the mouse ear vesicant model

S Dachir, E Fishbeine, Y Meshulam… - Human & …, 2002 - journals.sagepub.com
… effective treatment to skin injuries following exposure to sulfur mustard (HD) has yet been
found. In the present study, the mouse ear vesicant model was applied to awake mice in order …

Modulation of sulfur mustard-induced inflammation and gene expression by olvanil in the hairless mouse vesicant model

CLK Sabourin, MM Danne, KL Buxton… - Journal of Toxicology …, 2003 - Taylor & Francis
… exposure to sulfur mustard [bis(2-chloroethyl) sulfide (SM)] … in the hairless mouse vesicant
model that could be used as … sulfur mustard injury in the hairless mouse vesicant model at …

Mustards and vesicants

RA Young, CB Bast - Handbook of toxicology of chemical warfare agents, 2015 - Elsevier
… Most of the discussion of sulfur mustards in this chapter will be about distilled sulfur … these
agents through the development of experimental models for vesicant-induced injury, as well as …

Mustard vesicants

R Malaviya, DE Heck, RP Casillas… - Chemical Warfare …, 2019 - taylorfrancis.com
… to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L). Cell Biol. Toxicol.
… against topically applied sulfur mustard in the mouse ear vesicant model (MEVM). J. Appl. …

Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model

YC Chang, JD Wang, KK Svoboda, RP Casillas… - Toxicology and applied …, 2013 - Elsevier
… to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), … SM using the mouse ear
vesicant model (MEVM) showed … skin within 24 h of vesicant exposure in a defensive response to …

A 7‐Day Mouse Model to Assess Protection from Sulfur Mustard (SM) Skin Injury

MC Babin, KM Ricketts, RC Kiser… - Journal of Toxicology …, 2003 - Taylor & Francis
vesicant model and its use to assess topically delivered pharmacological protection against
SM skin injury. Interestingly, few in vivo studies with vesicant models … pig vesicant model

… of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

AT Black, PJ Hayden, RP Casillas, DE Heck… - Toxicology and applied …, 2010 - Elsevier
Sulfur mustard is a potent vesicant that induces inflammation, … the model sulfur mustard
vesicant, 2-chloroethyl ethyl sulfide, … These effects are similar to human responses to vesicants in …