… Analysis of signaling networks requires a combination of experimental and theoretical … of
models. This review focuses on theoretical approaches to understanding cell signaling networks…

… spatial modeling can effectively address in cell signaling, and different overall strategies for
developing models of cellular pathways. Using our web-based Virtual Cell (VCell) modeling …

… modeling to eukaryotic biology. We focus on logic-based models of biochemical signaling
networks … of logic-based models to gene regulatory networks (11), and models of intercellular …

… The development of computational models and the integration of these models with … of
computational models of biochemical networks and describe the insights gained from models that …

… into a unified cell signaling network. The longest path in the cell signaling network we have
… to the class I PI3K enzyme and further through class III PI3K to various cellular responses. …

… graphs to cellular signaling networks such as the identification of signaling pathways and …
to check the consistency of experimental data with a given network structure. In logical …

… signal flow is tightly regulated with positiveand negative feedbacks and is bidirectional with
commands traveling both fromoutside-in and inside-out, dynamic models … signaling network …

… pragmatic simplifications for future models and look ahead to the new frontiers of modeling
… a signaling network, which collectively integrates external cues to change cellular behavior. …

… modeling of complex cellular networks that takes structural diversity of mechanistic dynamic
models … hypotheses into libraries of mathematical models, on rigorously relating model …

… 2, we review previous related work on cell signaling networks. In Section 3, we lay out our
statistical model in detail, elaborating the cell, tissue, population, and measurement levels. …