[HTML][HTML] Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised …

M Rutherford, LA Ramenghi, AD Edwards… - The Lancet …, 2010 - thelancet.com
… the MRI scans obtained during the neonatal period in a nested substudy of the TOBY trial. …
of prolonged moderate hypothermia in newborns with hypoxic–ischaemic encephalopathy. …

Whole-body hypothermia, cerebral magnetic resonance biomarkers, and outcomes in neonates with moderate or severe hypoxic-ischemic encephalopathy born at …

S Thayyil, P Montaldo, V Krishnan, P Ivain… - JAMA Network …, 2023 - jamanetwork.com
… imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial.  …
Conclusions and Relevance In this nested cohort study, whole-body hypothermia was not …

Is it time for a randomized controlled trial of hypothermia for mild hypoxic-ischemic encephalopathy?

S Chawla, SV Bates, S Shankaran - The Journal of pediatrics, 2020 - jpeds.com
… Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia
in neonatal encephalopathy after moderate hypothermia in neonatal encephalopathy: a …

[HTML][HTML] Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open …

D Azzopardi, NJ Robertson, A Bainbridge… - The Lancet …, 2016 - thelancet.com
… Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic
encephalopathy: a nested substudy of a randomised controlled trial. …

Patient selection and prognostication with hypothermia treatment

M Thoresen - Seminars in Fetal and Neonatal Medicine, 2010 - Elsevier
… In a nested substudy of the TOBY data (40% of the infants), MRI was undertaken at a median
age of 8 days and the PPV of abnormal scan was equally good in the two groups: 83% for …

Hypothermia: a systematic review and meta-analysis of clinical trials

PS Shah - Seminars in Fetal and Neonatal Medicine, 2010 - Elsevier
… ), (b) degree of encephalopathy – moderate vs severe HIE (… of moderate-to-severe involvement
18 ) and (c) target temperature range (moderate hypothermia ≤34 C vs mild hypothermia

Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy: A Multicenter Pilot Randomized Clinical Trial

P Montaldo, M Cirillo, C Burgod, E Caredda… - JAMA Network …, 2024 - jamanetwork.com
… Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic
encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. …

Measured energy expenditure in mildly hypothermic critically ill patients with traumatic brain injury: a sub-study of a randomized controlled trial

EJ Ridley, AR Davies, S Bernard, C McArthur, L Murray… - Clinical Nutrition, 2021 - Elsevier
… critically ill population, and the first prospectively nested within a RCT. In … In hypothermic
patients with severe TBI, mild hypothermia to 33 C decreased energy expenditure by 20%, and …

Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial

JLY Cheong, L Coleman, RW Hunt… - … of pediatrics & …, 2012 - jamanetwork.com
… -treated group compared with the normothermia-treated group found in this study further
supports hypothermia as a treatment for moderate to severe HIE in terms of reducing the …

[HTML][HTML] … targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after …

C Robba, R Badenes, D Battaglini, L Ball, F Sanfilippo… - Critical Care, 2022 - Springer
Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain.
The primary aim of this study was to describe the values of partial pressure of oxygen …