[HTML][HTML] Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

HG Novrup, V Bracchi-Ricard, DG Ellman… - Journal of …, 2014 - Springer
… Our results show that systemic administration of either XPro1595 or etanercept by subcutaneous
injection failed to improve functional recovery and reduce tissue damage in our mouse …

A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury

BK Kwon, E Okon, J Hillyer, C Mann… - Journal of …, 2011 - liebertpub.com
… and neutrophils in lesion site from 18-72h post injury after severe or moderateSystemic
administration of magnesium has typically been with magnesium sulfate at doses of 100, 300, or …

A systematic review of directly applied biologic therapies for acute spinal cord injury

BK Kwon, EB Okon, W Plunet, D Baptiste… - Journal of …, 2011 - liebertpub.com
… An increasing number of therapies for spinal cord injury (SCI) … these are administered as
soon as possible after injury with the … the moderate injury (but not in the other two injury models). …

Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats

A Sauerbeck, DL Schonberg, JL Laws… - Experimental neurology, 2013 - Elsevier
… be to deliver an iron chelator systemically. Thus, we tested oral delivery of deferasirox (Exjade) …
Rats then received a moderate spinal contusion injury using the Infinite Horizons device (…

Therapeutic hypothermia for spinal cord injury

WD Dietrich III - Critical care medicine, 2009 - journals.lww.com
… contusive SCI, early cooling strategies using systemically administered mild hypothermia
(33C) have been reported to improve locomotive function as well as forelimb gripping strength …

Systemic administration of allogeneic cord blood mononuclear cells in adults with severe acute contusion spinal cord injury: phase 1/2a pilot clinical study–safety and …

VA Smirnov, SM Radaev, YV Morozova, SI Ryabov… - World Neurosurgery, 2022 - Elsevier
Objective Phase 1 of the SUBSCI I/IIa (Systemic Umbilical Cord Blood Administration in
Patients with Acute Severe Contusion Spinal Cord Injury) study focused on safety and primary …

Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury

ME Baltin, DE Sabirova, EI Kiseleva… - Experimental Brain …, 2021 - Springer
… in improvement of locomotion after SCI compared to systemic administration. LC–MS/MS
data … In rats with mild damage of the spinal cord, it was shown that functional recovery quickly …

Pharmacological management of secondary spinal cord injury

A Baroncini, N Maffulli, J Eschweiler… - Expert opinion on …, 2021 - Taylor & Francis
systematic search of the available literature on Pubmed, Google scholar, Embase, and Scopus,
and on a systematic … been to reduce spasticity, with moderate results in the clinical trials …

High dose methylprednisolone in the management of acute spinal cord injury–a systematic review from a clinical perspective

DJ Short, WS El Masry, PW Jones - Spinal cord, 2000 - nature.com
… Conclusion: The evidence produced by this systematic review does not support the use of
high dose methylprednisolone in acute spinal cord injury to improve neurological recovery. A …

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

J Ruschel, F Hellal, KC Flynn, S Dupraz, DA Elliott… - Science, 2015 - science.org
… a moderate, mid-thoracic spinal cord contusion, a clinically relevant SCI model (28). …
contusion injury, epoB administration (0.75 mg/kg BW) reduced fibrotic scarring at the injury