Modification of mesenchymal stem cells for cardiac regeneration

H Song, BW Song, MJ Cha, IG Choi… - Expert Opinion on …, 2010 - Taylor & Francis
Importance of the field: Mesenchymal stem cells (MSCs) have the greatest potential for use
in cell-based therapy of human heart diseases, especially in myocardial infarcts. The …

[HTML][HTML] Improved therapeutics of modified mesenchymal stem cells: an update

DKW Ocansey, B Pei, Y Yan, H Qian, X Zhang… - Journal of translational …, 2020 - Springer
modification approaches can be broadly divided into two groups to include genetic modification
and preconditioning modification (… We discuss the application of the improved modified

[HTML][HTML] Modification of mesenchymal stem cells for cartilage-targeted therapy

J Huang, Q Liu, J Xia, X Chen, J Xiong, L Yang… - Journal of translational …, 2022 - Springer
… homing capacity of MSCs and targeted modification can improve their ability to promote …
effect of stem cells in joints and highlight progress toward the targeted modification of MSCs. In …

Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia

K Toyama, O Honmou, K Harada, J Suzuki… - Experimental …, 2009 - Elsevier
… transplantation of human mesenchymal stem cells (hMSCs) … effects of angiopoietin-1
gene-modified hMSC (Ang-hMSC), … of Ang-1 and VEGF gene-modified hMSCs (Ang-VEGF-hMSC) …

Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation

KN Sivanathan, S Gronthos, D Rojas-Canales… - Stem Cell Reviews and …, 2014 - Springer
mesenchymal stem cells (MSC) as immune regulatory cells represent a promising approach
to modulate T cell … Zealand as the world’s first stem cell drug from Osiris therapeutics for the …

Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium

J Huang, Z Zhang, J Guo, A Ni, A Deb, L Zhang… - Circulation …, 2010 - Am Heart Assoc
… vivo salutary effects of genetic modification of stem cells. Specifically, overexpression of …
mesenchymal stem cells have been extensively investigated for their potential in developing cell

[HTML][HTML] Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia

L McGinley, J McMahon, P Strappe, F Barry… - Stem cell research & …, 2011 - Springer
cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal
stem cells (… of time, without adversely affecting cell viability and differentiation capacity, is …

Epitranscriptomic modifications in mesenchymal stem cell differentiation: advances, mechanistic insights, and beyond

J Zheng, Y Lu, Y Lin, S Si, B Guo, X Zhao… - Cell Death & …, 2024 - nature.com
… of different RNA modifications in MSCs, their roles in regulating stem cell behavior, and their
modifications impact MSC biology, the functional significance of individual modifications, …

Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia

H Liu, O Honmou, K Harada, K Nakamura, K Houkin… - Brain, 2006 - academic.oup.com
Intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone marrow
reduces infarction size and ameliorates functional deficits in rat cerebral ischaemia models. …

[HTML][HTML] A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies

P Saeedi, R Halabian, AAI Fooladi - Stem cell investigation, 2019 - ncbi.nlm.nih.gov
… Multipotent mesenchymal stem cells (MSCs) have been considerably inspected as effective
tool for cell-based therapy of inflammatory, immune-mediated, and degenerative diseases, …