Potassium channel modulation and auditory processing

MR Brown, LK Kaczmarek - Hearing research, 2011 - Elsevier
… The majority of studies investigating the regulation of intrinsic excitability of auditory
neurons have also been carried out in the MNTB, and these are the focus of this review. …

Modulation of neuronal potassium channels during auditory processing

J Wu, LK Kaczmarek - Frontiers in Neuroscience, 2021 - frontiersin.org
modulated in response to changes in the auditory environment. Here, we review work focusing
on how such modulation of potassium channels … accuracy of these neurons. We describe …

Modulation of the kv3. 1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons

CM Macica, CAA von Hehn, LY Wang… - Journal of …, 2003 - Soc Neuroscience
… isoforms of the Kv3.1 potassium channel that are expressed in these neurons, Kv3.1a and
… Our results suggest that modulation of Kv3.1 by phosphorylation allows auditory neurons to …

Gradients and Modulation of K+ Channels Optimize Temporal Accuracy in Networks of Auditory Neurons

LK Kaczmarek - PLoS Computational Biology, 2012 - journals.plos.org
channels than its neighbors. In this study, computational models based on measurements in
auditory neuronsauditory neurons, rapid adjustments of levels of potassium current within …

Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels

LK Kaczmarek, A Bhattacharjee, R Desai, L Gan… - Hearing research, 2005 - Elsevier
… of potassium channels, particularly the Kv3.1 channel and the way it is regulated in auditory
… It will also briefly cover other potassium channels including the Kv1 family channels, sodium …

Modulation of Kv3. 1b potassium channel phosphorylation in auditory neurons by conventional and novel protein kinase C isozymes

P Song, LK Kaczmarek - Journal of Biological Chemistry, 2006 - ASBMB
… In fast-spiking neurons such as those in the medial … ) in the auditory brainstem, Kv3.1
potassium channels are required for high frequency firing. The Kv3.1b splice variant of this channel

Modulation of potassium conductances optimizes fidelity of auditory information

LK Kaczmarek - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Potassium channels in auditory neurons are rapidly modified by changes in the auditory
two major classes of potassium channel on the response of neurons receiving synaptic inputs …

Modulators of Kv3 potassium channels rescue the auditory function of fragile X mice

L El-Hassar, L Song, WJT Tan, CH Large… - Journal of …, 2019 - Soc Neuroscience
… suggest that the modulation of the Kv3.1 channel may have … mRNA encoding the Kv3.1
potassium channel was one of the first … on K + currents and firing patterns of MNTB neurons in …

Acoustic environment determines phosphorylation state of the Kv3. 1 potassium channel in auditory neurons

P Song, Y Yang, M Barnes-Davies… - Nature …, 2005 - nature.com
… To determine whether auditory stimulation modulates channel phosphorylation in vivo, we
examined Kv3.1b phosphorylation after acoustic stimulation of awake rats using click trains to …

Sound stimulation modulates high‐threshold K+ currents in mouse auditory brainstem neurons

KE Leao, RN Leao, AS Deardorff… - European Journal of …, 2010 - Wiley Online Library
… of sensory activity on K + channel expression, mice were … the neuronal activity in the auditory
system. To confirm that the sound presentation increased neuronal activity of MNTB neurons