… ) induced rat colon carcinogenesis by evaluating the circulatory antioxidant status and colonic
… crypt foci (ACF) formation and multiplicity in the colon of experimental groups. Wistar male …

… modulation of NF-κB and its related genes [17]. In the present study, modulatory efficacy of
hesperetin on colon carcinogenesis initiated with DMH was investigated in male Wistar rats …

… rats shows its efficacy against colon cancer. RA also reduces the tumour burden in carcinogen
treated rats (… detoxification mechanism by modulating the phase I and phase II enzymes. …

… These data reveal the modulatory role of caraway in a dose-… profile in DMH-induced rat colon
cancer. Caraway at a dose … chemically by the modulation of intestinal and colonic LPO and …

… from alliums probably exert their effects through modulation of carcinogen metabolism (30,31)…
Many of the agents we tested in this study have been shown to prevent colon cancer in the …

… In this regard modulation of xenobiotic metabolizing enzymes comprising phase I (cytochrome
b5, cytochrome b5 reductase, cytochromeP450, cytochromeP450 reductase, …

… lesions were recently described in the rat colon (21). … colon carcinogenesis in rats (or mice)
after carcinogen injection. 2) We ranked the agents, according to their potency to inhibit colon …

… 1, 2-dimethylhydrazine (DMH) induced rat colon carcinogenesis is one of the widely studied
… was to investigate the chemopreventive efficacy of troxerutin employing DMH induced colon …

… as the incidences of ACF and their subtypes, adenomas and adenocarcinomas have to be
considered holistically before making conclusions on the modulating efficacy of a compound. …

… lead to colon cancer. Rat and human ACF show defects in DNA content, morphology, and
proliferation kinetics, and mutations have been detected in key genes involved in colon cancer …