… C4 levels, the C4a molecule is strictly speaking isotype independent. … C4A is an isotypic
variant of the C4 molecule, while C4a is a protein fragment that is released from the C4 molecule …

… Investigating the molecular basis leading to complete C4A and C4B deficiencies will help in
… complete C4A- and C4B-deficient patient and the characterization of the molecular basis of …

… We present an integrated and updated view of complement based on structural … to complement.
Finally, we discuss how the structural and mechanistic understanding of the complement …

… the C4A and C4B locus-encoded a-chains have a molecular … time a molecular basis for the
difference between all C4A and C4B … to the A or B locus on the basis of charge differences14 …

… and determine the molecular basis for the complete C4A and … the molecular basis of complete
complement C4A and C4B … 1213 from exon 29 of both C4A and C4B genes. This mutation …

… By using purified C4A and C4B isolated from individual donors known serolog… molecular
basis for the differences in their respective hemolytic activities. It was found that the C4B:C4A …

… data analysis, assisted by GRA ÁSand ZP prepared the C4A-containing plasma. RTK
purified C4A and conducted the mass spectrometry analysis with assistance from SVPGRA …

… complement system. In this review, we summarize the current concepts on the 1–2–3 loci
model of C4A … , functional and serological diversities of the C4A and C4B proteins. The …

… G~ Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0)
as … Molecular genetics of the fourth component of human complement and steroid 21-…

… Structural information from other less common variants of each isotype, C4A 1 and C4B 5,
contributes to our understanding of the molecular basis of the isotypic properties and on the …