… system is responsible for regulating a wide variety of physiological and behavioral rhythms
(1,2). The mammalian circadian system is organized in a hierarchy of oscillators. At the top of …

… that both transcriptional and posttranscriptional mechanisms underlie the mammalian
circadian clock. We also find that circadian modulation of RNAPII recruitment and chromatin …

… To understand better the powerful role of the circadian clock … of the molecular mechanisms
used to generate circadian rhythms of … mechanisms to generate circadian rhythms of protein …

… on understanding the molecular mechanism of circadian clocks in mammals, and we have
… the generation of circadian rhythms of mammals [1,2]. The discovery of the Clock gene using …

… 4 The core, accessory and output molecular mechanisms of the mammalian circadian
clock. BMAL1/CLOCK heterodimer (green) binds to Ebox (yellow) in clock oscillating genes (red) …

… the molecular mechanism for generating the circadian rhythm is … with our recent findings on
the mechanism in mammals. … molecular mechanism of the circadian clock in mammals with …

… Genetic, biochemical and genomic approaches have led to major advances in
understanding the molecular and cellular basis of mammalian circadian clock components and …

… Indeed, dysfunction of circadian rhythms as a result of shift work or neurodegenerative disorders,
for … Additionally, circadian clocks can be used to our benefit when treating patients with …

… of major clock components. This review describes the recent advances in our knowledge of
the molecular clockwork in mammals; in particular, the contribution of new clock components …

… The structure of CLOCK: BMAL1 represents a starting … mammalian circadian clock. Many
of the previously identified mutations on CLOCK and BMAL1 can be mapped onto the structure …