Deconstructing the perineuronal net: cellular contributions and molecular composition of the neuronal extracellular matrix

KA Giamanco, RT Matthews - Neuroscience, 2012 - Elsevier
… of their molecular components and how they interact. … critical to dissect their molecular
composition, which will then … study was to unravel the molecular composition of PNNs to determine …

Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components

D Carulli, KE Rhodes, DJ Brown… - Journal of …, 2006 - Wiley Online Library
… Here, 1) we studied the molecular composition of PNNs by immunohistochemistry (IHC) for
CSPGs, TN-R, and HA; 2) we identified the cell types synthesizing CSPGs, TN-R, HASs, and …

Perineuronal nets: past and present

MR Celio, R Spreafico, S De Biasi… - Trends in …, 1998 - cell.com
perineuronal net, is now recognized as a genuine entity in neurocytology. It represents a
complex of extracellular matrix molecules … in the case of the perineuronal net. This review traces …

Perineuronal net formation and structure in aggrecan knockout mice

KA Giamanco, M Morawski, RT Matthews - Neuroscience, 2010 - Elsevier
Perineuronal nets (PNNs) are specialized substructures of … of their precise molecular
composition has been elusive. In … key insight into the precise molecular composition of PNNs. …

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

JW Fawcett, T Oohashi, T Pizzorusso - Nature Reviews Neuroscience, 2019 - nature.com
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing
structures that surround the soma and dendrites of various mammalian …

Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets

RT Matthews, GM Kelly, CA Zerillo, G Gray… - Journal of …, 2002 - Soc Neuroscience
… neurons can directly regulate the composition of the ECM that surrounds them. Finally, we
have demonstrated that the cell-specific composition of perineuronal nets is mediated, at least …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet … with signaling molecules and regulate …

Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex—A Possible Link to Microcircuitry Specialization

I Banovac, MV Prkačin, I Kirchbaum… - Molecular …, 2024 - Springer
… The literature review shows that the laminar distribution and morphological and molecular
… Therefore, this study aims to explore molecular composition, morphological features, and …

Axon initial segment ensheathed by extracellular matrix in perineuronal nets

G Brückner, S Szeöke, S Pavlica, J Grosche, J Kacza - Neuroscience, 2006 - Elsevier
… analyze perineuronal nets associated with large motoneurons in the mouse superior colliculus.
The molecular composition of perineuronal nets was … domains of perineuronal nets were …

From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

B Sanchez, P Kraszewski, S Lee… - Journal of …, 2023 - Wiley Online Library
… FIGURE 1 Overview of the structure and composition of perineuronal nets (PNNs). Many …
(GAG) chains and bind molecules such as inhibitory molecules, cytokines, and growth factors. …