Perineuronal Nets: From Structure to Neurological Disorders

X Li, N Li, P Zhao, D Ren, B Luo… - Current Medicinal …, 2024 - ingentaconnect.com
… effect and interact with signaling molecules to regulate synaptic plasticity and neuronal
activity. In this review, we provide an overview of the composition, structure, and functions of PNN…

Perineuronal net density in schizophrenia: A systematic review of postmortem brain studies

JRF Lisboa, O Costa, GH Pakes, DAE Colodete… - Schizophrenia …, 2024 - Elsevier
… Representation of the structural organization of the perineuronal nets (PNNs). … of molecules,
such as neurotrophins, semaphorin 3 A, and the transcription factor OTX2. These molecules

Potential involvement of perineuronal nets in brain aging: an anatomical point of view

J Yamada, S Jinno - Factors Affecting Neurological Aging, 2021 - Elsevier
… The perineuronal net , a meshworklike aggregate in the extracellular matrix, enwraps … In
particular, expression patterns and molecular composition of PNNs in the brain are altered with …

Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican

E Favuzzi, A Marques-Smith, R Deogracias… - Neuron, 2017 - cell.com
Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide
composition for the net… Here we identify the molecular mechanism through which the PNN …

Perineuronal nets in the auditory system

M Sonntag, M Blosa, S Schmidt, R Rübsamen… - Hearing Research, 2015 - Elsevier
… (PNs) are a unique and complex meshwork of specific extracellular matrix molecules that …
the composition of the perineuronal net. The main components and their potential composition

The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

T Vo, D Carulli, EME Ehlert, JCF Kwok, G Dick… - Molecular and Cellular …, 2013 - Elsevier
… Sema3A-positive nets were no longer observed in the area … We conclude that the
chemorepulsive axon guidance molecule … chemorepulsive axon guidance molecules like Sema3A …

Very long-term memories may be stored in the pattern of holes in the perineuronal net

RY Tsien - Proceedings of the National Academy of …, 2013 - National Acad Sciences
molecule pass on their status to newer copies to preserve the information. A major problem
is that individual intracellular molecules … -rich matrix called the perineuronal net (PNN) has …

Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets

Y Bekku, WD Su, S Hirakawa, R Fässler… - Molecular and Cellular …, 2003 - Elsevier
… LPs are important molecules like “wedge” in the construction and stability of hyaluronan/lecticans
matrix, it might be possible to think that neurons are regulating the composition of their …

Postnatal development of GABAergic interneurons and perineuronal nets in mouse temporal cortex subregions

H Ueno, S Suemitsu, S Murakami, N Kitamura… - International Journal of …, 2017 - Elsevier
… Components of WFA-positive ECM molecules in the upper level of layer 1 of the PRh, DLEnt,
and DIEnt Next, we analyzed the composition of WFA-positive ECM molecules in the upper …

Regulation of perineuronal nets in the adult cortex by the activity of the cortical network

G Devienne, S Picaud, I Cohen, J Piquet… - Journal of …, 2021 - Soc Neuroscience
… SIGNIFICANCE STATEMENT The perineuronal net is an extracellular matrix, which … local
decrease of perineuronal net density. Our results indicate that perineuronal nets are regulated …