Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer

JP Gillet, MM Gottesman - Current pharmaceutical …, 2011 - ingentaconnect.com
… levels of ABC transporters, by de… the molecular detection of ABC transporters and other
families of highly homologous MDR-linked genes encoding, for example, the uptake transporters (…

Molecular basis of multidrug transport by ABC transporters

MA Seeger, HW van Veen - Biochimica Et Biophysica Acta (BBA)-Proteins …, 2009 - Elsevier
… The expected asymmetry of a vanadate-trapped ABC transporter however was not detected
in a corresponding MsbA-ADP-V i crystal structure of MsbA, which was indistinguishable …

The role of ABC transporters in drug resistance, metabolism and toxicity

H Glavinas, P Krajcsi, J Cserepes… - Current drug …, 2004 - ingentaconnect.com
… We know very little as yet about the molecular mechanism and structure of these proteins, …
In this case radioactive labeling was utilized to detect molecules trapped inside the vesicles. …

[HTML][HTML] Diverse relations between ABC transporters and lipids: An overview

J Neumann, D Rose-Sperling, UA Hellmich - Biochimica et Biophysica Acta …, 2017 - Elsevier
… also affect how ABC transporters interact with other hydrophobic molecules, such as …
molecules were detected for BtuCD using MS, but LDAO (lauryl dimethylamine N-oxide) molecules

[HTML][HTML] Molecular detection of lacrimal apparatus and ocular surface-related ABC transporter genes

B Kleinsasser, F Garreis, M Musialik, I Zahn… - Annals of Anatomy …, 2024 - Elsevier
ABC transporters are expressed at the ocular surface and in the human lacrimal apparatus.
Using RT-PCR, all ABC transporters … the presence of all ABC transporters in the samples …

The role of ABC transporters in clinical practice

GD Leonard, T Fojo, SE Bates - The oncologist, 2003 - academic.oup.com
… Having outlined the difficulties in detecting MDR1/P-gp in cancer cells, it is not surprising that
… As molecular targets, ABC transporters may prove invaluable in facilitating the optimal use …

Multidrug resistance in parasites: ABC transporters, P-glycoproteins and molecular modelling

PM Jones, AM George - International journal for parasitology, 2005 - Elsevier
… in these areas that the role of ABC transporters in parasitic multidrug resistance mechanisms
may … We discuss ABC transporters in parasites, and conclude with an example of molecular

Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes

JP Gillet, T Efferth, D Steinbach, J Hamels… - Cancer research, 2004 - AACR
… As a strategy to explore which ABC transporters might function as drug transporters, we
performed COMPARE analysis with compounds included in the NCI’s Standard Agent database …

ABC transporters affect the detection of intracellular oxidants by fluorescent probes

J Procházková, L Kubala, H Kotasová… - Free Radical …, 2011 - Taylor & Francis
… Second, we aimed to show that ROS detection could be affected by the endogenous expression
of ABC transporters. We showed that DCFH is a substrate of BCRP and, therefore, PMA-…

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions

AM Calcagno, IW Kim, CP Wu, S Shukla… - Current drug …, 2007 - ingentaconnect.com
… of ABC transporter expression would be helpful to detect any impending drug-drug interactions.
Many of the earliest detection systems for expression of ABC transporter genes utilized …