… A total of 54 tricyclic triazinone analogues as PKC-θ inhibitors involved in this study were
collected from the same group [10], [11]. Their capabilities to inhibit human recombinant PKC …

… of above molecules, we prompted to synthesize the Bis(indolyl)-triazinones, new analogs
of … for the synthesis of bis(indolyl) triazinone analogues. The anti-tumor activities of these …

… In the present work, the pIC 50 of tricyclic triazinone analogues as PKC-θ inhibitors was
computed by CORAL-QSAR using Monte Carlo algorithm with two target functions TF 1 and TF 2 …

… Furthermore, the data of compounds 3c, 4c and 6c indicate that rigid triazinone analogue
4c is higher than both rotatable hydrazine carbothioamide derivative 3c and the extended …

… protein, we conducted molecular docking to analyze its binding mode (PDB ID: 7ALV). (53)
L38 was found to occupy a protein … The carbonyl group on the triazinone fragment formed a …

… SAR by synthesis of a range of analogues of the HTS hits, with … core ring when compared
to the triazinones in the present study (… of action of triazinones 1, 2, and 9 against CRPC cells. …

… 1, we examined ten structural analogues (compounds 2–11, … docking simulation (Supporting
Information Table S1). However, the proposed biological activities of structural analogues …

… effective molecules, we have performed different chemical modifications of the triazinone
core… 23 and 24, and the 3-pyridinyl analogue 26 showed interesting IC 50 values, ranging from …

… From the docking studies, compounds 5c and 10c are the most active analogs, with the
lowest binding energies. These two compounds exhibited inconsequential recognition at the …

… To investigate the potential insecticidal mechanism, molecular docking studies were … In
the case of VI-6b (Figure 3a), the triazinone ring formed hydrogen bonds with Arg646 and …