… , and injuries, also impair skin homeostasis. Genetic risk factors play a … skin diseases, with
mutations in genes encoding skin structural proteins found to be associated with some skin …

… Connective tissue diseases manifesting in the skin are often … of the molecular and immune
drivers involved in the … , and mixed connective tissue disease. Recent research advances …

… heterogeneous group of diseases that affect the skin. Mycosis … of MF/SS, the molecular and
clinical features currently used for … key molecular mechanisms that can act as drivers for the …

… In particular, if we gain sufficient knowledge of its underlying molecular pathophysiology,
then we can identify disease-driving pathways and target relevant proteins. Or, better yet, it may …

… Yet, there is a paucity of molecular studies describing the driving factors behind ethnic …
Our recent work using skin and 3D human skin equivalents (HSE) also demonstrates that skin …

… as both sensor and effector molecules for LPS and do not … ASC and the still inactive effector
molecule pro-caspase-1 (14)… adhesion molecule 1, vascular cell adhesion molecule 1 and E-…

… physiology and disease. An improved understanding of the epigenomic influences that
drive … -mediated skin diseases is essential to elucidate the fundamental molecular drivers of …

… treat genetic skin diseases. Thus, understanding the molecular pathology of skin diseases
can … This chapter highlights some of the recent discoveries on the molecular pathology of skin …

… targeting molecules implicated in aberrant neutrophil degranulation can modulate disease
severity … In addition, an important role of neutrophil exosomes in skin autoinflammation in GPP …

… To characterise the molecular mechanisms underpinning … representing normal sun exposed
skin/peri-lesional skin (n = 26)… analysis (GSEA) identified several molecular pathways and/or …