Chalcone scaffolds as anticancer drugs: a review on molecular insight in action of mechanisms and anticancer properties
… In summary, the antitumor activity of the chalcone scaffolds is observed via distinct
mechanisms adopted by these molecules underlying their inhibitory activity (Scheme 5). …
mechanisms adopted by these molecules underlying their inhibitory activity (Scheme 5). …
Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
… compound revealed that the chalcone scaffold is observed to … This binding orientation of
the chalcone scaffold is consistent … chalcone-coumarin hybrids as potential lead molecules for …
the chalcone scaffold is consistent … chalcone-coumarin hybrids as potential lead molecules for …
Chalcone scaffold in anticancer armamentarium: a molecular insight
… Chalcone is the well exploited scaffold in the anticancer domain. The molecular mechanism
of chalcone … review provides the most recent updates on anticancer potential of chalcones. …
of chalcone … review provides the most recent updates on anticancer potential of chalcones. …
Chalcone scaffolds, bioprecursors of flavonoids: Chemistry, bioactivities, and pharmacokinetics
… This review provides an insight into the chemistry, … potential, chalcone scaffolds/chalcone
derivatives and … discovery toward promising drug lead molecules/drug candidates. …
derivatives and … discovery toward promising drug lead molecules/drug candidates. …
Functionalization of the chalcone scaffold for the discovery of novel lead compounds targeting fungal infections
F Bonvicini, GA Gentilomi, F Bressan, S Gobbi… - Molecules, 2019 - mdpi.com
… chalcone as a privileged scaffold, suitable for the development of antifungal agents. … some
liabilities of the chalcone scaffold and helped us to gain insight into the chemical features …
liabilities of the chalcone scaffold and helped us to gain insight into the chemical features …
Chalcone: a promising bioactive scaffold in medicinal chemistry
G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
… Chalcones are a class of privileged scaffolds with high … Numerous functional modifications
of chalcones have been … -infectious diseases, and uses of chalcones over the past decade, …
of chalcones have been … -infectious diseases, and uses of chalcones over the past decade, …
Network pharmacology, molecular docking and molecular dynamics simulation of chalcone scaffold-based compounds targeting breast cancer receptors
NZ Ismail, M Khairuddean, S Abubakar… - Journal of Biomolecular …, 2023 - Taylor & Francis
… In order to evaluate the compounds pertaining to the chalcone scaffold, we used DataWarrior
Chemical Data Analysis and Visualization software V5.5.0 (López-López et al., Citation…
Chemical Data Analysis and Visualization software V5.5.0 (López-López et al., Citation…
Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight
… chalcone scaffold were historically considered excellent candidates for the development of
anticancer drugs. Chalcones … promising therapeutic role of chalcones in TNBC management. …
anticancer drugs. Chalcones … promising therapeutic role of chalcones in TNBC management. …
Chalcones: a valid scaffold for monoamine oxidases inhibitors
F Chimenti, R Fioravanti, A Bolasco… - Journal of medicinal …, 2009 - ACS Publications
… selectivity, the molecular modeling study was … insight on the inhibition mechanism and the
rational drug design of more potent/selective hMAO inhibitors based on the chalcone scaffold…
rational drug design of more potent/selective hMAO inhibitors based on the chalcone scaffold…
Privileged scaffold chalcone: synthesis, characterization and its mechanistic interaction studies with BSA employing spectroscopic and chemoinformatics approaches
… To probe a deep insight into the binding interaction of chalcone with BSA, FT-IR spectra
were analyzed. Proteins exhibit two bands in the infrared region. The amide I band in the region …
were analyzed. Proteins exhibit two bands in the infrared region. The amide I band in the region …
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