… of ROR-γt modulators, both agonist and inverse-agonists. Here, we review advances in the
development of ROR-γt … on the rich crystallography landscape for ROR-γt co-crystals that has …

… For example, using these small molecule compounds, we demonstrated that RORγt is
required for the maintenance of IL-17 expression in mouse and human effector T cells. Here, we …

… of three small-molecule RORγt inhibitors that potently … molecular mechanism underlying
the effect of these compounds, we characterized the direct transcriptional targets of RORγt …

… 1 and inverse agonist 2 bind with the RORγt-LBD, we performed molecular docking by using
the Schrodinger 3.5 software package. The co-crystal structure of RORγt-LBD (PDB code: …

… the reported RORγt sterol and … small molecule RORγt agonists, their structural insights, and
the common ground of their MOAs. Finally, we discuss the potential of small molecule RORγt …

… insight into the molecular mechanisms that lead to agonism, antagonism, or inverse agonism.
We report new molecular mechanisms for RORγt … new mechanistic insights should prove …

… the molecular events that contribute to the ability of T‐bet, GATA‐3 and RORγt to define T …
unexpected insights into the molecular mechanisms utilized in T helper cell differentiation. …

… ROR-γt Ser-489 phosphorylation and the AhR–ROR-γt complex (18), we further studied
whether ROR-γt Ser-489 phosphorylation and the AhR–ROR-γt … data showed that ROR-γt Ser-…

… , we explore the small molecules that target retinoid-related orphan receptor γt (RORγt), a …
for Th17 cell differentiation, targeting RORγt via small molecular inverse agonists may be a …

… Importantly, similar to the reported effect of RORγT, RORγ also drove the expression of
other Th17 signature molecules such as IL-17F, CCR6, IL-22, and IL-23R (Fig. 2, C and D). …