[HTML][HTML] Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapy

MR Asgharzadeh, J Barar, MM Pourseif… - BioImpacts …, 2017 - ncbi.nlm.nih.gov
… importance of molecular machineries related to the pH dysregulation within TME and that
the use of relevant inhibitors against key regulators of pH might suppress tumor progression, …

Extracellular HSP90 machineries build tumor microenvironment and boost cancer progression

P Poggio, M Sorge, L Seclì… - Frontiers in Cell and …, 2021 - frontiersin.org
… Emerging data indicate that these functions are essential for tumor growth and progression.
… the molecular mechanisms at the basis of their functions in the tumor microenvironment may …

[HTML][HTML] Dysregulated pH in tumor microenvironment checkmates cancer therapy

J Barar, Y Omidi - BioImpacts: BI, 2013 - ncbi.nlm.nih.gov
… Thus, the molecular machineries of this transitional step may provide potential target for
inhibition of type 3 EMT. In a study, the expressions of E-cadherin and ZO-1 were investigated in …

Impact of the physical microenvironment on tumor progression and metastasis

F Spill, DS Reynolds, RD Kamm, MH Zaman - Current opinion in …, 2016 - Elsevier
tumor microenvironment and how its properties affect tumor … We will then introduce some
of the key intracellular molecules … cells that can activate mechanotransductive machinery and …

Turning cold into hot: firing up the tumor microenvironment

Q Duan, H Zhang, J Zheng, L Zhang - Trends in cancer, 2020 - cell.com
… Then, we discuss how innate immune sensing machinery, genetic alterations of oncogenic
… Those so-called hot tumors are characterized by T cell infiltration and molecular signatures …

Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?

F Chen, X Qi, M Qian, Y Dai, Y Sun - Protein & cell, 2014 - academic.oup.com
… -responsive molecularmachineries or the signals from extracellular environments are
actively at play under in vivo conditions. In contrast to other factors, the tumor microenvironment

Matrix metalloproteinases shape the tumor microenvironment in cancer progression

S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
… The tumor microenvironment (TME) is formed by cells as well as by biochemical and biophysical
components of the ECM and their intricate interactions in and around a solid tumor mass…

Metabolic codependencies in the tumor microenvironment

P Dey, AC Kimmelman, RA DePinho - Cancer Discovery, 2021 - AACR
… into the regulation as well as the machinery involved in macropinocytosis and may provide
… In addition, signaling molecules from cancer cells can change the identity of immune cells …

Roles of circRNAs in the tumour microenvironment

Q Zhang, W Wang, Q Zhou, C Chen, W Yuan, J Liu… - Molecular cancer, 2020 - Springer
… for cancer treatment, but their clinical applications are limited due to their toxic side effects [1].
The tumour microenvironment (TME… and therapeutic treatment of cancer [2,3,4]. Therefore, …

Tumor microenvironment: the role of the tumor stroma in cancer

H Li, X Fan, JM Houghton - Journal of cellular biochemistry, 2007 - Wiley Online Library
… DNA mutations and the suppression of DNA repair machinery. The mutator phenotype of …
molecules unique to the tumor microenvironment will provide strategies for modifying the tumor