Molecular mechanism of evolution and human infection with SARS-CoV-2

J He, H Tao, Y Yan, SY Huang, Y Xiao - Viruses, 2020 - mdpi.com
… Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects
… studied the molecular mechanisms of human infection with SARS-CoV-2 and SARS-CoV by …

The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection

L Santacroce, IA Charitos, DM Carretta… - Journal of Molecular …, 2021 - Springer
… 70% to SARS-CoV, the virus responsible of SARS. In the first half … named the new
coronavirus as SARS-CoV-2. This article … and pathophysiologic mechanisms of SARS-CoV-2. …

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
… Uncovering the molecular mechanism that underlies the entry of SARS-CoV-2 is one of the
most important puzzles in understanding how to block its infection. Coronaviruses enter host …

Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Y Duan, H Zhou, X Liu, S Iketani, M Lin, X Zhang… - Nature, 2023 - nature.com
… We found that the mechanism for SARS-CoV-2 resistance to nirmatrelvir could be
generalized to two common evolutionary pathways (Fig. 5). The first route is to directly lower the …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
COVID-19 pandemic caused by infection with severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) … , appropriately, on the mechanisms of SARS-CoV-2 entry into host cells, …

Cell entry mechanisms of SARS-CoV-2

J Shang, Y Wan, C Luo, G Ye, Q Geng… - Proceedings of the …, 2020 - National Acad Sciences
… that part of SARS-CoV-2 spike molecules had been cleaved … molecules to calibrate
SARS-CoV-2 pseudovirus entry, while using the uncleaved spike molecules to calibrate SARS-CoV

SARS-CoV-2 and the nervous system: from clinical features to molecular mechanisms

M Pennisi, G Lanza, L Falzone, F Fisicaro… - … journal of molecular …, 2020 - mdpi.com
… enzyme-2 (ACE2) receptor. Given the similarity between SARS-CoV and SARS-CoV-2,
the … the exact pathogenic mechanism of SARS-CoV-2 is not yet completely understood. …

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

H Zhang, JM Penninger, Y Li, N Zhong… - Intensive care medicine, 2020 - Springer
… A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
was detected in Wuhan, China, in December 2019. The disease (COVID-19) …

[HTML][HTML] Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

G Kokic, HS Hillen, D Tegunov, C Dienemann… - Nature …, 2021 - nature.com
… drug for the treatment of COVID-19 patients. The active form … (RdRp) of coronaviruses including
SARS-CoV-2. Remdesivir is … to establish the molecular mechanism of remdesivir-induced …

Analysis of the molecular mechanism of SARS-CoV-2 antibodies

D Jin, J Wei, J Sun - Biochemical and biophysical research communications, 2021 - Elsevier
… research and treatment of SARS-CoV-2. In this study, … SARS-CoV-2 infection. According to
their different binding epitope regions in RBD or NTD, they are classified, and the mechanism