… In this review, we discuss recent advances in the identification of mitochondrial sirtuin (SIRT3–5)
substrates and describe the mitochondrial programs that are regulated by SIRT3–5 in …

… mechanism of sirtuins and how this information might be employed to develop inhibitors
and other molecular … We also cover physiological regulation of sirtuin activity and how these …

… -molecule inhibitors or activators of mitochondrial SIRTs … the molecular mechanisms of
mitochondrial SIRTs in cancer are complex and diverse, and their specific molecular mechanisms …

… However, the molecular mechanism behind this protective effect for Sir2.1 against genotoxic
and neurotoxic stress remains unclear. In this context, recent studies in mammal models of …

… On the basis of our results, we suggest that the inhibition of SphK1 by Aβ 1–42 is a crucial
point in activating the molecular mechanisms of cell death. An analysis of the selected …

… physiological substrates of the mitochondrial Sirtuins, we used proteins isolated in their
partly acetylated form from natural sources (ie, from mammalian mitochondria). These proteins, …

… mitochondrial localization; and sirtuin 6 (SIRT6) and sirtuin 7 (… revealed that some
sirtuin-activating molecules have beneficial … This review aims to explore the molecular …

… due to their localization in the mitochondrial matrix. First, we will … Finally, we will discuss
how mitochondrial sirtuins regulate … Details of mitochondrial sirtuins in metabolism will be …

… of those sirtuin family members that are uniquely mitochondrial in their localization, we will
also discuss other sirtuins that can influence mitochondrial … The molecular basis for how Sirt1 …

… to investigate the molecular mechanisms of resveratrol-dependent Sirtuin modulation. …
the substrate fluorophore, which indicates a mechanism for Sirtuin modulation by resveratrol-like …