The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection

L Santacroce, IA Charitos, DM Carretta… - Journal of Molecular …, 2021 - Springer
… 70% to SARS-CoV, the virus responsible of SARS. In the first half … thus definitively named
the new coronavirus as SARS-CoV-2. This … and pathophysiologic mechanisms of SARS-CoV-2. …

SARS-CoV-2 and the nervous system: from clinical features to molecular mechanisms

M Pennisi, G Lanza, L Falzone, F Fisicaro… - … journal of molecular …, 2020 - mdpi.com
… , SARS-CoV has a well… SARS-CoV and SARS-CoV-2, the pathogenesis underlying these
infections may be the same [19,20,21], although the exact pathogenic mechanism of SARS-CoV

Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
… well as peptide- and small-molecule compound-based antiviral therapies. … SARS-CoV-2
and host receptors Uncovering the molecular mechanism that underlies the entry of SARS-CoV-…

Molecular mechanism of evolution and human infection with SARS-CoV-2

J He, H Tao, Y Yan, SY Huang, Y Xiao - Viruses, 2020 - mdpi.com
… Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects
… studied the molecular mechanisms of human infection with SARS-CoV-2 and SARS-CoV by …

Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Y Duan, H Zhou, X Liu, S Iketani, M Lin, X Zhang… - Nature, 2023 - nature.com
SARS-CoV-2 and has been approved to treat COVID-19 1 , 2 . As an RNA virus characterized
by high mutation rates, whether SARS-CoV-… The molecular mechanisms for this observed …

SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management

L Wu, AM O'Kane, H Peng, Y Bi, D Motriuk-Smith… - Biochemical …, 2020 - Elsevier
… sequelae for SARS-CoV-2 infection. Here we will summarize the relationship … SARS-CoV-2
and cardiovascular diseases, and discuss possible mechanisms of action behind SARS-CoV-…

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

W Gu, H Gan, Y Ma, L Xu, ZJ Cheng, B Li, X Zhang… - Virology journal, 2022 - Springer
… , understanding the inhibitory effect of SARS-CoV-2 on innate … summarizes the molecular
mechanism by which SARS-CoV-… to fine-tune the outcome of SARS-CoV-2 infection and the …

Analysis of the molecular mechanism of SARS-CoV-2 antibodies

D Jin, J Wei, J Sun - Biochemical and biophysical research communications, 2021 - Elsevier
… the current research and treatment of SARS-CoV-2. In … SARS-CoV-2 infection. According
to their different binding epitope regions in RBD or NTD, they are classified, and the mechanism

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 M pro by QM/MM computational methods

K Świderek, V Moliner - Chemical Science, 2020 - pubs.rsc.org
SARS-CoV-2 Mpro is one of the enzymes essential for the replication process of the virus
responsible for the COVID-19 pandemic. This work is focused on exploring its proteolysis …

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

H Zhang, JM Penninger, Y Li, N Zhong… - Intensive care medicine, 2020 - Springer
SARS-CoV spike protein has a strong … SARS-CoV-2 and SARS-CoV spike proteins share
76.5% identity in amino acid sequences [6] and, importantly, the SARS-CoV-2 and SARS-CoV