Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling
L Zhang, H Jiang, X Cao, H Zhao, F Wang, Y Cui… - European Journal of …, 2009 - Elsevier
… )-gossypol could be converted into more active derivatives. When compared with (−)-gossypol, …
contributor to the anticancer activity of chiral gossypol seemed to be the phenolic groups, …
contributor to the anticancer activity of chiral gossypol seemed to be the phenolic groups, …
Recent advances in gossypol derivatives and analogs: a chemistry and biology view
Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
… antiapoptotic Bcl-2 proteins, and molecular modeling studies suggested that the isopropyl
groups … from apogossypol was the key molecule for the synthesis of corresponding derivatives. …
groups … from apogossypol was the key molecule for the synthesis of corresponding derivatives. …
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
… Gossypol has gained considerable research interest due to its attractive biological activities,
especially antitumor and antivirus. Gossypol derivatives … of gossypol and its derivatives as …
especially antitumor and antivirus. Gossypol derivatives … of gossypol and its derivatives as …
Synthesis and antiviral activities of novel gossypol derivatives
J Yang, F Zhang, J Li, G Chen, S Wu, W Ouyang… - Bioorganic & medicinal …, 2012 - Elsevier
… H 5 N 1 than the other gossypol derivatives. Meanwhile, these … The absence of the COONa
group in gossypol derivatives … Molecular modeling analysis demonstrated that compounds …
group in gossypol derivatives … Molecular modeling analysis demonstrated that compounds …
Reaction chemistry of gossypol and its derivatives
JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
… gossypol derivatives for medicinal applications. This review summarizes current knowledge
about gossypol… synthesized by using IR and UV spectroscopy as well as molecular modeling …
about gossypol… synthesized by using IR and UV spectroscopy as well as molecular modeling …
Conformational analysis of gossypol and its derivatives by molecular mechanics
CL Beisel, MK Dowd, PJ Reilly - Journal of Molecular Structure: Theochem, 2005 - Elsevier
… Molecular simulations were conducted on a Dell PC with an 800-MHz Pentium III processor.
MM3(2000) was obtained from Professor NL Allinger of the University of Georgia. All …
MM3(2000) was obtained from Professor NL Allinger of the University of Georgia. All …
Design and synthesis of a gossypol derivative with improved antitumor activities
… for the synthesis of a new derivative of gossypol, 6,7,69,79-… compound, (–)-gossypol, in
inhibiting the human prostate … at 1 lM, whereas (–)-gossypol at 10 lM only inhibited less than 50% …
inhibiting the human prostate … at 1 lM, whereas (–)-gossypol at 10 lM only inhibited less than 50% …
A gossypol derivative as an efficient corrosion inhibitor for St2 steel in 1 M HCl+ 1 M KCl: An experimental and theoretical investigation
… The new type of corrosion inhibitor based on a gossypol derivative was first introduced.
The anti-corrosion performance of 6-aminopenicillanic acid sodium gossypol (APASG) for St2 …
The anti-corrosion performance of 6-aminopenicillanic acid sodium gossypol (APASG) for St2 …
Gossypol with hydrophobic linear esters exhibits enhanced antitumor activity as an inhibitor of antiapoptotic proteins
Y Lu, S Wu, Y Yue, S He, J Li, J Tang… - ACS Medicinal …, 2016 - ACS Publications
… Compounds 27 and 28, analogues of the gossypol derivative megosin with different chain
lengths… structure, (4) so we used this form in our molecular model study. One advantage of the …
lengths… structure, (4) so we used this form in our molecular model study. One advantage of the …
[PDF][PDF] … AND PHYSICO-CHEMICAL ANALYSIS METHODS IN THE PREDICTION OF BIOLOGICAL ACTIVITY AND QUALITY CONTROL OF GOSSYPOL DERIVATIVES
EV USPENSKAYA, PА ZABORKINA, EA RYNDINA… - Int J App …, 2022 - academia.edu
… Objective: The purpose of this work was to evaluate in silico biological activity profiles of real
and virtual molecular structures of gossypol derivatives and to develop methods of Physico-…
and virtual molecular structures of gossypol derivatives and to develop methods of Physico-…
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