Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling

L Zhang, H Jiang, X Cao, H Zhao, F Wang, Y Cui… - European Journal of …, 2009 - Elsevier
… )-gossypol could be converted into more active derivatives. When compared with (−)-gossypol, …
contributor to the anticancer activity of chiral gossypol seemed to be the phenolic groups, …

Recent advances in gossypol derivatives and analogs: a chemistry and biology view

Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
… antiapoptotic Bcl-2 proteins, and molecular modeling studies suggested that the isopropyl
groups … from apogossypol was the key molecule for the synthesis of corresponding derivatives. …

Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design

Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Gossypol has gained considerable research interest due to its attractive biological activities,
especially antitumor and antivirus. Gossypol derivatives … of gossypol and its derivatives as …

Synthesis and antiviral activities of novel gossypol derivatives

J Yang, F Zhang, J Li, G Chen, S Wu, W Ouyang… - Bioorganic & medicinal …, 2012 - Elsevier
… H 5 N 1 than the other gossypol derivatives. Meanwhile, these … The absence of the COONa
group in gossypol derivativesMolecular modeling analysis demonstrated that compounds …

Reaction chemistry of gossypol and its derivatives

JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
gossypol derivatives for medicinal applications. This review summarizes current knowledge
about gossypol… synthesized by using IR and UV spectroscopy as well as molecular modeling

Conformational analysis of gossypol and its derivatives by molecular mechanics

CL Beisel, MK Dowd, PJ Reilly - Journal of Molecular Structure: Theochem, 2005 - Elsevier
Molecular simulations were conducted on a Dell PC with an 800-MHz Pentium III processor.
MM3(2000) was obtained from Professor NL Allinger of the University of Georgia. All …

Design and synthesis of a gossypol derivative with improved antitumor activities

Y Zhan, G Jia, D Wu, Y Xu, L Xu - Archiv der Pharmazie: An …, 2009 - Wiley Online Library
… for the synthesis of a new derivative of gossypol, 6,7,69,79-… compound, (–)-gossypol, in
inhibiting the human prostate … at 1 lM, whereas (–)-gossypol at 10 lM only inhibited less than 50% …

A gossypol derivative as an efficient corrosion inhibitor for St2 steel in 1 M HCl+ 1 M KCl: An experimental and theoretical investigation

E Berdimurodov, A Kholikov, K Akbarov, L Guo… - Journal of Molecular …, 2021 - Elsevier
… The new type of corrosion inhibitor based on a gossypol derivative was first introduced.
The anti-corrosion performance of 6-aminopenicillanic acid sodium gossypol (APASG) for St2 …

Gossypol with hydrophobic linear esters exhibits enhanced antitumor activity as an inhibitor of antiapoptotic proteins

Y Lu, S Wu, Y Yue, S He, J Li, J Tang… - ACS Medicinal …, 2016 - ACS Publications
… Compounds 27 and 28, analogues of the gossypol derivative megosin with different chain
lengths… structure, (4) so we used this form in our molecular model study. One advantage of the …

[PDF][PDF] … AND PHYSICO-CHEMICAL ANALYSIS METHODS IN THE PREDICTION OF BIOLOGICAL ACTIVITY AND QUALITY CONTROL OF GOSSYPOL DERIVATIVES

EV USPENSKAYA, PА ZABORKINA, EA RYNDINA… - Int J App …, 2022 - academia.edu
… Objective: The purpose of this work was to evaluate in silico biological activity profiles of real
and virtual molecular structures of gossypol derivatives and to develop methods of Physico-…